Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database)

Sachin Kumar, Salil V. Deo, Salah E. Altarabsheh, Shannon M Dunlay, Nagaraju Sarabu, Basar Sareyyupoglu, Yakov Elgudin, Benjamin Medalion, Chantal ElAmm, Mahazarin Ginwalla, Michael Zacharias, Rodolpho Benatti, Guilherme H. Oliveira, Ahmet Kilic, Gregg C. Fonarow, Soon J. Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ Sharing registry (1991 to 2014) was performed to evaluate recipient profile and clinical outcome of patients with HCV seropositive (HCV +ve) and seronegative (HCV -ve). Adjusted results of early mortality and late survival were compared between cohorts. From 23,507 patients (mean age 52 years; 75% men), 481 (2%) were HCV +ve (mean age 52 years; 77% men). Annual proportion of HCV +ve recipients was comparable over the study period (range 1.3% to 2.7%; p = 0.2). The HCV +ve cohort had more African-American (22% vs 17%; p = 0.01), previous left ventricular assist device utilization (21% vs 14%; p

Original languageEnglish (US)
JournalAmerican Journal of Cardiology
DOIs
StateAccepted/In press - Feb 9 2016

Fingerprint

Heart Transplantation
Hepatitis C
Hepacivirus
Databases
Survival
Registries
Heart-Assist Devices
African Americans
Transplants
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database). / Kumar, Sachin; Deo, Salil V.; Altarabsheh, Salah E.; Dunlay, Shannon M; Sarabu, Nagaraju; Sareyyupoglu, Basar; Elgudin, Yakov; Medalion, Benjamin; ElAmm, Chantal; Ginwalla, Mahazarin; Zacharias, Michael; Benatti, Rodolpho; Oliveira, Guilherme H.; Kilic, Ahmet; Fonarow, Gregg C.; Park, Soon J.

In: American Journal of Cardiology, 09.02.2016.

Research output: Contribution to journalArticle

Kumar, S, Deo, SV, Altarabsheh, SE, Dunlay, SM, Sarabu, N, Sareyyupoglu, B, Elgudin, Y, Medalion, B, ElAmm, C, Ginwalla, M, Zacharias, M, Benatti, R, Oliveira, GH, Kilic, A, Fonarow, GC & Park, SJ 2016, 'Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database)', American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2016.04.023
Kumar, Sachin ; Deo, Salil V. ; Altarabsheh, Salah E. ; Dunlay, Shannon M ; Sarabu, Nagaraju ; Sareyyupoglu, Basar ; Elgudin, Yakov ; Medalion, Benjamin ; ElAmm, Chantal ; Ginwalla, Mahazarin ; Zacharias, Michael ; Benatti, Rodolpho ; Oliveira, Guilherme H. ; Kilic, Ahmet ; Fonarow, Gregg C. ; Park, Soon J. / Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database). In: American Journal of Cardiology. 2016.
@article{737831eefb594c04b4e671fad914d79f,
title = "Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database)",
abstract = "Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ Sharing registry (1991 to 2014) was performed to evaluate recipient profile and clinical outcome of patients with HCV seropositive (HCV +ve) and seronegative (HCV -ve). Adjusted results of early mortality and late survival were compared between cohorts. From 23,507 patients (mean age 52 years; 75{\%} men), 481 (2{\%}) were HCV +ve (mean age 52 years; 77{\%} men). Annual proportion of HCV +ve recipients was comparable over the study period (range 1.3{\%} to 2.7{\%}; p = 0.2). The HCV +ve cohort had more African-American (22{\%} vs 17{\%}; p = 0.01), previous left ventricular assist device utilization (21{\%} vs 14{\%}; p",
author = "Sachin Kumar and Deo, {Salil V.} and Altarabsheh, {Salah E.} and Dunlay, {Shannon M} and Nagaraju Sarabu and Basar Sareyyupoglu and Yakov Elgudin and Benjamin Medalion and Chantal ElAmm and Mahazarin Ginwalla and Michael Zacharias and Rodolpho Benatti and Oliveira, {Guilherme H.} and Ahmet Kilic and Fonarow, {Gregg C.} and Park, {Soon J.}",
year = "2016",
month = "2",
day = "9",
doi = "10.1016/j.amjcard.2016.04.023",
language = "English (US)",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Effect of Hepatitis C Positivity on Survival in Adult Patients Undergoing Heart Transplantation (from the United Network for Organ Sharing Database)

AU - Kumar, Sachin

AU - Deo, Salil V.

AU - Altarabsheh, Salah E.

AU - Dunlay, Shannon M

AU - Sarabu, Nagaraju

AU - Sareyyupoglu, Basar

AU - Elgudin, Yakov

AU - Medalion, Benjamin

AU - ElAmm, Chantal

AU - Ginwalla, Mahazarin

AU - Zacharias, Michael

AU - Benatti, Rodolpho

AU - Oliveira, Guilherme H.

AU - Kilic, Ahmet

AU - Fonarow, Gregg C.

AU - Park, Soon J.

PY - 2016/2/9

Y1 - 2016/2/9

N2 - Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ Sharing registry (1991 to 2014) was performed to evaluate recipient profile and clinical outcome of patients with HCV seropositive (HCV +ve) and seronegative (HCV -ve). Adjusted results of early mortality and late survival were compared between cohorts. From 23,507 patients (mean age 52 years; 75% men), 481 (2%) were HCV +ve (mean age 52 years; 77% men). Annual proportion of HCV +ve recipients was comparable over the study period (range 1.3% to 2.7%; p = 0.2). The HCV +ve cohort had more African-American (22% vs 17%; p = 0.01), previous left ventricular assist device utilization (21% vs 14%; p

AB - Concerns exist regarding orthotropic heart transplantation in hepatitis C virus (HCV) seropositive recipients. Thus, a national registry was accessed to evaluate early and late outcome in HCV seropositive recipients undergoing heart transplant. Retrospective analysis of the United Network for Organ Sharing registry (1991 to 2014) was performed to evaluate recipient profile and clinical outcome of patients with HCV seropositive (HCV +ve) and seronegative (HCV -ve). Adjusted results of early mortality and late survival were compared between cohorts. From 23,507 patients (mean age 52 years; 75% men), 481 (2%) were HCV +ve (mean age 52 years; 77% men). Annual proportion of HCV +ve recipients was comparable over the study period (range 1.3% to 2.7%; p = 0.2). The HCV +ve cohort had more African-American (22% vs 17%; p = 0.01), previous left ventricular assist device utilization (21% vs 14%; p

UR - http://www.scopus.com/inward/record.url?scp=84966746474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966746474&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2016.04.023

DO - 10.1016/j.amjcard.2016.04.023

M3 - Article

C2 - 27189814

AN - SCOPUS:84966746474

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

ER -