Effect of heparin sodium on postoperative inflammation after adult cataract surgery

Sunil Ganekal, Syril Dorairaj, Varun Ganekal

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the effect of use of ringer lactate solution supplemented with heparin sodium in patients undergoing cataract surgery. Materials and Methods: In a prospective, double-blind, interventional study, 200 patients were included and were randomized to undergo cataract surgery using ringer lactate solution with or without 10 IU/ml heparin. All patients underwent phacoemulsification with hydrophobic acrylic foldable intraocular lens (IOL) implantation. The severity of anterior chamber inflammation and amount of pigment deposition of IOL was assessed by slit lamp biomicroscopy on day 1, 7, 28 and after 8 weeks postoperatively. Results: Mean age in treatment and control group was 63.0± 11.5 years and 65.1±12.7 years respectively. A significant reduction in the severity of inflammatory cellular activity (p=0.001), flare (p=0.001) and pigment deposition on IOL (p=0.001) was noted on day 1 in the heparin treated group compared to the control group. However, no significant difference was observed in the amount of inflammatory activity as well as IOL pigment deposition beyond 1 week postoperatively. The inflammatory activity resolved almost completely in both the groups by the end of 8 weeks postoperatively. Conclusion: Our study showed the beneficial effect of addition of heparin to irrigating solution during cataract surgery. Heparin treated eyes demonstrated a reduction in the early postoperative inflammation and IOL pigment deposition. The anti-inflammatory effect was observed in the early postoperative period.

Original languageEnglish (US)
Pages (from-to)699-702
Number of pages4
JournalIndian Journal of Clinical and Experimental Ophthalmology
Volume7
Issue number4
DOIs
StatePublished - 2021

Keywords

  • Cataract surgery
  • Heparin
  • Intraocular inflammation

ASJC Scopus subject areas

  • Ophthalmology

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