Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: Importance of achieving a complete response

Morie A. Gertz, Martha Q. Lacy, Angela Dispenzieri, Suzanne R. Hayman, Shaji K. Kumar, Nelson Leung, Dennis A. Gastineau

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Our objective was to determine whether the goal of high-dose therapy should be a partial hematologic response or a complete response. We analyzed 282 consecutive stem cell transplant patients. A partial hematologic response was achieved in 108 patients (38%), and 93 (33%) achieved a complete hematologic response. Survival rates of patients with complete, partial, or no response were significantly different (p<0.001), even after eliminating bias from early death. The degree of response was affected by the intensity of chemotherapy conditioning, septal thickness, and cardiac biomarkers. Hematologic response translates to longer survival.

Original languageEnglish (US)
Pages (from-to)1415-1418
Number of pages4
JournalHaematologica
Volume92
Issue number10
DOIs
StatePublished - Oct 1 2007

Keywords

  • Amyloidosis
  • Chemotherapy
  • Complete response
  • Immunoglobulin free light chain
  • Stem cell transplant
  • Survival

ASJC Scopus subject areas

  • Hematology

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