Effect of hematin in porphyric neuropathy

E. Peter Bosch; Claus A. Pierach; Irene Bossenmaier; Ruth Cardinal; Mark Thorson

doi:10.1212/wnl.27.11.1053

Effect of hematin in porphyric neuropathy

E. Peter Bosch, Claus A. Pierach, Irene Bossenmaier, Ruth Cardinal, Mark Thorson

Neurology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable Improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month after the onset of the porphyric relapse had no effect on recovery of the residual neuropathy. We believe hematin may be effective in the treatment of porphyric neuropathy, if administered before irreversible neuronal damage has occurred.

Original language	English (US)
Pages (from-to)	1053-1056
Number of pages	4
Journal	Neurology
Volume	27
Issue number	11
DOIs	https://doi.org/10.1212/wnl.27.11.1053
State	Published - Nov 1977

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/wnl.27.11.1053

Cite this

@article{e5b081e4f61f4f33847e41aa2b23ad1c,

title = "Effect of hematin in porphyric neuropathy",

abstract = "Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable Improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month after the onset of the porphyric relapse had no effect on recovery of the residual neuropathy. We believe hematin may be effective in the treatment of porphyric neuropathy, if administered before irreversible neuronal damage has occurred.",

author = "Bosch, {E. Peter} and Pierach, {Claus A.} and Irene Bossenmaier and Ruth Cardinal and Mark Thorson",

year = "1977",

month = nov,

doi = "10.1212/wnl.27.11.1053",

language = "English (US)",

volume = "27",

pages = "1053--1056",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - Effect of hematin in porphyric neuropathy

AU - Bosch, E. Peter

AU - Pierach, Claus A.

AU - Bossenmaier, Irene

AU - Cardinal, Ruth

AU - Thorson, Mark

PY - 1977/11

Y1 - 1977/11

N2 - Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable Improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month after the onset of the porphyric relapse had no effect on recovery of the residual neuropathy. We believe hematin may be effective in the treatment of porphyric neuropathy, if administered before irreversible neuronal damage has occurred.

AB - Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable Improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month after the onset of the porphyric relapse had no effect on recovery of the residual neuropathy. We believe hematin may be effective in the treatment of porphyric neuropathy, if administered before irreversible neuronal damage has occurred.

UR - http://www.scopus.com/inward/record.url?scp=0017717021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017717021&partnerID=8YFLogxK

U2 - 10.1212/wnl.27.11.1053

DO - 10.1212/wnl.27.11.1053

M3 - Article

C2 - 200860

AN - SCOPUS:0017717021

SN - 0028-3878

VL - 27

SP - 1053

EP - 1056

JO - Neurology

JF - Neurology

IS - 11

ER -

Effect of hematin in porphyric neuropathy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this