Effect of head-up tilt-table testing on left ventricular longitudinal strain in patients with neurocardiogenic syncope

Ramil Goel, Giuseppe Caracciolo, Susan Wilansky, Luis Scott, Jagat Narula, Partho P. Sengupta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent studies have shown conflicting data regarding left ventricular (LV) function in patients with neurocardiogenic syncope, with some investigators reporting a marked decrease in LV end-systolic wall stress and stress-corrected fractional shortening. We sought to determine the characteristics of resting LV deformation in patients with neurocardiogenic syncope by selective motion tracking of subendocardial and subepicardial regions using speckle tracking echocardiography. We assessed resting LV function in 82 patients undergoing head-up tilt-table (HUTT) testing. Patients were divided into 3 groups based on a positive HUTT test with associated co-morbid conditions (n = 30), no associated co-morbid conditions (n = 30), or negative HUTT results (n = 22). LV longitudinal, circumferential, and radial strains were obtained by speckle tracking echocardiography of subendocardial and subepicardial regions in each group and compared with resting LV deformation in 20 healthy control subjects. Compared with endocardial longitudinal strain in control subjects, that in patients with positive HUTT results was attenuated, irrespective of co-morbid conditions (p <0.05). Circumferential and radial strains did not differ among groups. On multivariate logistic regression analysis, endocardial longitudinal strain was an independent predictor (odds ratio, 1.16; p = 0.01) of positive HUTT test results. In conclusion, resting LV longitudinal strain is attenuated in patients with positive HUTT test results. Overall, these results may suggest that an increase in resting LV contractility is not a prerequisite for development of neurocardiogenic syncope.

Original languageEnglish (US)
Pages (from-to)1252-1257
Number of pages6
JournalAmerican Journal of Cardiology
Volume112
Issue number8
DOIs
StatePublished - Oct 15 2013

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Vasovagal Syncope
Tilt-Table Test
Head
Left Ventricular Function
Echocardiography
Healthy Volunteers
Logistic Models
Odds Ratio
Regression Analysis
Research Personnel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of head-up tilt-table testing on left ventricular longitudinal strain in patients with neurocardiogenic syncope. / Goel, Ramil; Caracciolo, Giuseppe; Wilansky, Susan; Scott, Luis; Narula, Jagat; Sengupta, Partho P.

In: American Journal of Cardiology, Vol. 112, No. 8, 15.10.2013, p. 1252-1257.

Research output: Contribution to journalArticle

Goel, Ramil ; Caracciolo, Giuseppe ; Wilansky, Susan ; Scott, Luis ; Narula, Jagat ; Sengupta, Partho P. / Effect of head-up tilt-table testing on left ventricular longitudinal strain in patients with neurocardiogenic syncope. In: American Journal of Cardiology. 2013 ; Vol. 112, No. 8. pp. 1252-1257.
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