Effect of h-2 genes on expression of HLA-b27 and yersinia-induced arthritis

C. L. Nickerson, K. L. Hogen, H. S. Luthra, C. S. David

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

HLA-B*2705 transgenic mice were continuously backcrossed to mice of the BIO background with various haplotypes. A high level of expression of the HLA-B27 protein was detected on peripheral blood lymphocytes (PBLs) from mice homozygous for H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes by FACS analysis with the ME-1 antibody. A lower level of expression of B27 was observed on PBLs from H-2v mice. Little or no expression of B27 was detected on PBLs from H-2q or H-2d mice. We hypothesize that the HLA-B27 heavy chain is analogous to and competes with endogenous class I heavy chains in the H-2d, H-2q and H-2v haplotypes. Interestingly, other studies in our laboratory have demonstrated that mice with the H-2d and H-2q haplotypes with deletions of certain T cell receptor subsets are more prone to Yersinia-induced arthritis (YIA). Therefore, the mouse model of YIA may provide insights into the mechanisms of HLA-B27-linked spondyloarthropathies in man.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume19
Issue numberS87
DOIs
StatePublished - Jan 1 1990

Keywords

  • H-2 genes
  • HLA-B27 transgenic mice
  • Spondyloarthropathy
  • T cell receptor subsets
  • Yersinia-induced arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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