Effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin-induced diabetic rats

Mi Hyeon Jang, Hyun Kyung Chang, Min Chul Shin, Taeck Hyun Lee, Young Pyo Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immuno-histochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalJournal Pharmacological Sciences
Volume91
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Ginseng radix
  • Streptozotocin-induced diabetes
  • c-Fos

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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