Abstract
Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immuno-histochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.
Original language | English (US) |
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Pages (from-to) | 149-152 |
Number of pages | 4 |
Journal | Journal Pharmacological Sciences |
Volume | 91 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2003 |
Keywords
- Ginseng radix
- Streptozotocin-induced diabetes
- c-Fos
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology