Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes

S. K. Brockman, S. G. Younkin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rat at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.

Original languageEnglish (US)
Pages (from-to)409-411
Number of pages3
JournalBrain Research
Volume376
Issue number2
DOIs
StatePublished - Jun 25 1986

Keywords

  • acetylcholinesterase metabolism
  • acetylcholinesterase secretion
  • cultured embryonic rat myotube

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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