Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes

S. K. Brockman; S. G. Younkin

doi:10.1016/0006-8993(86)90210-6

Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes

S. K. Brockman, S. G. Younkin

Neuroscience

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rat at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.

Original language	English (US)
Pages (from-to)	409-411
Number of pages	3
Journal	Brain Research
Volume	376
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90210-6
State	Published - Jun 25 1986

Keywords

acetylcholinesterase metabolism
acetylcholinesterase secretion
cultured embryonic rat myotube

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)90210-6

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title = "Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes",

abstract = "We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rat at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.",

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AU - Younkin, S. G.

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N2 - We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rat at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.

AB - We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rat at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.

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Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes

Abstract

Keywords

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