Effect of extract of Ginkgo Biloba leaves on sciatic nerve regeneration in rats

Hao Dong Lin; Huan Wang; De Song Chen; Ji Feng Li; Yu Dong Gu

Effect of extract of Ginkgo Biloba leaves on sciatic nerve regeneration in rats

Hao Dong Lin, Huan Wang, De Song Chen, Ji Feng Li, Yu Dong Gu

Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To provide the promoting effect of extract of Ginkgo Biloba leaves (EGb₅₀) on nerve regeneration. Methods: Forty-eight male Sprague-Dawely rats were randomly divided into control group and EGb ₅₀ group. Sciatic nerve injury model was set up. Then 1 mL of normal saline in the control group, 1 mL of EGb₅₀ were administered every day after nerve injury. Electrophysiological, histological examinations and functional evaluation were used to assess nerve regeneration and the functional recovery in 2,4,6,8 weeks of operative intervals respectively. Results: The recovery rate of sciatic functional index (SFI), twitch tension and tetanic tension, motor nerve conduction velocity (MNCV), wet weight of triceps surae and the passing rate of myelinated nerve were significantly higher in EGb ₅₀ group in all the time point than that of control(P<0.01). Conclusions: EGb₅₀ has the effect of promoting regeneration of injuried peripheral nerve.

Original language	English (US)
Pages (from-to)	467-469+486
Journal	Fudan University Journal of Medical Sciences
Volume	33
Issue number	4
State	Published - Jul 2006

Keywords

Extract of Ginkgo Biloba leaves
Injury
Peripheral nerve
Regeneration

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Effect of extract of Ginkgo Biloba leaves on sciatic nerve regeneration in rats",

abstract = "Purpose: To provide the promoting effect of extract of Ginkgo Biloba leaves (EGb50) on nerve regeneration. Methods: Forty-eight male Sprague-Dawely rats were randomly divided into control group and EGb 50 group. Sciatic nerve injury model was set up. Then 1 mL of normal saline in the control group, 1 mL of EGb50 were administered every day after nerve injury. Electrophysiological, histological examinations and functional evaluation were used to assess nerve regeneration and the functional recovery in 2,4,6,8 weeks of operative intervals respectively. Results: The recovery rate of sciatic functional index (SFI), twitch tension and tetanic tension, motor nerve conduction velocity (MNCV), wet weight of triceps surae and the passing rate of myelinated nerve were significantly higher in EGb 50 group in all the time point than that of control(P<0.01). Conclusions: EGb50 has the effect of promoting regeneration of injuried peripheral nerve.",

keywords = "Extract of Ginkgo Biloba leaves, Injury, Peripheral nerve, Regeneration",

author = "Lin, {Hao Dong} and Huan Wang and Chen, {De Song} and Li, {Ji Feng} and Gu, {Yu Dong}",

year = "2006",

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pages = "467--469+486",

journal = "Fudan University Journal of Medical Sciences",

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T1 - Effect of extract of Ginkgo Biloba leaves on sciatic nerve regeneration in rats

AU - Lin, Hao Dong

AU - Wang, Huan

AU - Chen, De Song

AU - Li, Ji Feng

AU - Gu, Yu Dong

PY - 2006/7

Y1 - 2006/7

N2 - Purpose: To provide the promoting effect of extract of Ginkgo Biloba leaves (EGb50) on nerve regeneration. Methods: Forty-eight male Sprague-Dawely rats were randomly divided into control group and EGb 50 group. Sciatic nerve injury model was set up. Then 1 mL of normal saline in the control group, 1 mL of EGb50 were administered every day after nerve injury. Electrophysiological, histological examinations and functional evaluation were used to assess nerve regeneration and the functional recovery in 2,4,6,8 weeks of operative intervals respectively. Results: The recovery rate of sciatic functional index (SFI), twitch tension and tetanic tension, motor nerve conduction velocity (MNCV), wet weight of triceps surae and the passing rate of myelinated nerve were significantly higher in EGb 50 group in all the time point than that of control(P<0.01). Conclusions: EGb50 has the effect of promoting regeneration of injuried peripheral nerve.

AB - Purpose: To provide the promoting effect of extract of Ginkgo Biloba leaves (EGb50) on nerve regeneration. Methods: Forty-eight male Sprague-Dawely rats were randomly divided into control group and EGb 50 group. Sciatic nerve injury model was set up. Then 1 mL of normal saline in the control group, 1 mL of EGb50 were administered every day after nerve injury. Electrophysiological, histological examinations and functional evaluation were used to assess nerve regeneration and the functional recovery in 2,4,6,8 weeks of operative intervals respectively. Results: The recovery rate of sciatic functional index (SFI), twitch tension and tetanic tension, motor nerve conduction velocity (MNCV), wet weight of triceps surae and the passing rate of myelinated nerve were significantly higher in EGb 50 group in all the time point than that of control(P<0.01). Conclusions: EGb50 has the effect of promoting regeneration of injuried peripheral nerve.

KW - Extract of Ginkgo Biloba leaves

KW - Injury

KW - Peripheral nerve

KW - Regeneration

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Effect of extract of Ginkgo Biloba leaves on sciatic nerve regeneration in rats

Abstract

Keywords

ASJC Scopus subject areas

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