TY - JOUR
T1 - Effect of early statin therapy after acute coronary syndromes
T2 - A concise review of the recent data
AU - Bybee, Kevin A.
AU - Wright, R. Scott
AU - Kopecky, Stephen L.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - HMG Co-A reductase inhibitors(statins) have been shown, in three large randomized trials, to decrease adverse cardiac events in patients with clinically evident coronary artery disease. All of these trials have excluded patients with an acute coronary syndrome within the three months prior to enrollment. Statin therapy is thought to stabilize coronary plaque and decrease the risk of plaque rupture. Statins have been shown to quickly reduce levels of LDL-C in addition to altering systemic inflammatory responses, improving endothelial function, and reducing platelet aggregation and activation. These mechanisms are potentially beneficial in the setting of acute coronary syndromes, a time of profound plaque instability. There is a growing body of evidence supporting the early initiation of statin therapy in the setting of acute coronary syndromes. This paper reviews the available data from randomized-controlled trials and observational studies evaluating the effect of early statin initiation during, or soon following, an acute coronary syndrome.
AB - HMG Co-A reductase inhibitors(statins) have been shown, in three large randomized trials, to decrease adverse cardiac events in patients with clinically evident coronary artery disease. All of these trials have excluded patients with an acute coronary syndrome within the three months prior to enrollment. Statin therapy is thought to stabilize coronary plaque and decrease the risk of plaque rupture. Statins have been shown to quickly reduce levels of LDL-C in addition to altering systemic inflammatory responses, improving endothelial function, and reducing platelet aggregation and activation. These mechanisms are potentially beneficial in the setting of acute coronary syndromes, a time of profound plaque instability. There is a growing body of evidence supporting the early initiation of statin therapy in the setting of acute coronary syndromes. This paper reviews the available data from randomized-controlled trials and observational studies evaluating the effect of early statin initiation during, or soon following, an acute coronary syndrome.
KW - Acute coronary syndromes
KW - Coronary artery disease
KW - HMG Co-A reductase inhibitors
KW - Therapy
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U2 - 10.1097/00045415-200209000-00006
DO - 10.1097/00045415-200209000-00006
M3 - Review article
C2 - 12215193
AN - SCOPUS:0036734558
VL - 10
SP - 301
EP - 305
JO - Cardiology in Review
JF - Cardiology in Review
SN - 1061-5377
IS - 5
ER -