Effect of early statin therapy after acute coronary syndromes: A concise review of the recent data

Kevin A. Bybee, R. Scott Wright, Stephen L. Kopecky

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

HMG Co-A reductase inhibitors(statins) have been shown, in three large randomized trials, to decrease adverse cardiac events in patients with clinically evident coronary artery disease. All of these trials have excluded patients with an acute coronary syndrome within the three months prior to enrollment. Statin therapy is thought to stabilize coronary plaque and decrease the risk of plaque rupture. Statins have been shown to quickly reduce levels of LDL-C in addition to altering systemic inflammatory responses, improving endothelial function, and reducing platelet aggregation and activation. These mechanisms are potentially beneficial in the setting of acute coronary syndromes, a time of profound plaque instability. There is a growing body of evidence supporting the early initiation of statin therapy in the setting of acute coronary syndromes. This paper reviews the available data from randomized-controlled trials and observational studies evaluating the effect of early statin initiation during, or soon following, an acute coronary syndrome.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalCardiology in Review
Volume10
Issue number5
DOIs
StatePublished - Jan 1 2002

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Keywords

  • Acute coronary syndromes
  • Coronary artery disease
  • HMG Co-A reductase inhibitors
  • Therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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