Effect of dopaminergic drug treatment on surgical findings in prolactinomas

Maria Menucci, Alfredo Quinones-Hinojosa, Peter Burger, Roberto Salvatori

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

It has been reported that prolactinomas treated with Bromocriptine (BROM) show fibrosis that may interfere with complete surgical resection. The same has not been reported for Cabergoline (CAB). We retrospectively studied 24 consecutive patients (13 females, mean age 40 years, range 16-60) with histopathologically confirmed prolactinomas undergoing surgical resection at Johns Hopkins Hospital between 1992 and 2009. We compared these prolactinomas to 34 patients (22 females, mean age 42.9 years, range 15-75) with GH-secreting adenoma. The operative notes from 7 different neurosurgeons were reviewed to catalog the tumors as fibrous or not fibrous. Of the 24 prolactinomas, 21 (87.5%) were previously treated with DA. Indication for surgery was: DA resistance (n.5), DA intolerance (n.6), persistent mass effect (n.7) and CSF leak (n.3). Five (14.7%) of GH-secreting adenomas, were exposed to DA and/or somatostatin analogs. We found that 54% of prolactinomas and only 6% of GH-secreting adenomas were described as fibrous. 10/12 (77%) of prolactinomas exposed to BROM for at least 1 month, 2/9 (22%) exposed to CAB only, and 1/3 (33%) not previously treated were fibrous (P < 0.05). The mean BROM cumulative dose was 406 mg (range 75-1,375), while CAB dose was 28 mg (range 6-70). Only 18% of non-fibrous prolactinomas had been exposed to BROM. Only 3 patients had persistent biochemical remission (2 treated with CAB and 1 not treated). Patients exposed to BROM for at least 1 month are more likely to have tumor fibrosis than patients that are untreated or treated with CAB.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalPituitary
Volume14
Issue number1
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Prolactinoma
Dopamine Agents
Bromocriptine
Adenoma
Therapeutics
Fibrosis
Somatostatin
Neoplasms
cabergoline

Keywords

  • Cabergoline
  • Dopamine agonist
  • Pituitary adenoma
  • Prolactinoma
  • Tumor fibrosis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of dopaminergic drug treatment on surgical findings in prolactinomas. / Menucci, Maria; Quinones-Hinojosa, Alfredo; Burger, Peter; Salvatori, Roberto.

In: Pituitary, Vol. 14, No. 1, 03.2011, p. 68-74.

Research output: Contribution to journalArticle

Menucci, Maria ; Quinones-Hinojosa, Alfredo ; Burger, Peter ; Salvatori, Roberto. / Effect of dopaminergic drug treatment on surgical findings in prolactinomas. In: Pituitary. 2011 ; Vol. 14, No. 1. pp. 68-74.
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abstract = "It has been reported that prolactinomas treated with Bromocriptine (BROM) show fibrosis that may interfere with complete surgical resection. The same has not been reported for Cabergoline (CAB). We retrospectively studied 24 consecutive patients (13 females, mean age 40 years, range 16-60) with histopathologically confirmed prolactinomas undergoing surgical resection at Johns Hopkins Hospital between 1992 and 2009. We compared these prolactinomas to 34 patients (22 females, mean age 42.9 years, range 15-75) with GH-secreting adenoma. The operative notes from 7 different neurosurgeons were reviewed to catalog the tumors as fibrous or not fibrous. Of the 24 prolactinomas, 21 (87.5{\%}) were previously treated with DA. Indication for surgery was: DA resistance (n.5), DA intolerance (n.6), persistent mass effect (n.7) and CSF leak (n.3). Five (14.7{\%}) of GH-secreting adenomas, were exposed to DA and/or somatostatin analogs. We found that 54{\%} of prolactinomas and only 6{\%} of GH-secreting adenomas were described as fibrous. 10/12 (77{\%}) of prolactinomas exposed to BROM for at least 1 month, 2/9 (22{\%}) exposed to CAB only, and 1/3 (33{\%}) not previously treated were fibrous (P < 0.05). The mean BROM cumulative dose was 406 mg (range 75-1,375), while CAB dose was 28 mg (range 6-70). Only 18{\%} of non-fibrous prolactinomas had been exposed to BROM. Only 3 patients had persistent biochemical remission (2 treated with CAB and 1 not treated). Patients exposed to BROM for at least 1 month are more likely to have tumor fibrosis than patients that are untreated or treated with CAB.",
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