Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing

The MI-GENES Study (Myocardial Infarction Genes)

Sherry Ann N. Brown, Hayan Jouni, Tariq S. Marroush, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known. We hypothesized that disclosing genetic risk for CHD to individuals influences information seeking and sharing. Methods and Results - The MI-GENES study (Myocardial Infarction Genes) randomized participants (n=203) aged 45 to 65 years who were at intermediate CHD risk based on conventional risk factors and not on statins to receive their conventional risk score alone or also a genetic risk score based on 28 variants. CHD risk was disclosed by a genetic counselor and then discussed with a physician. Surveys assessing information seeking were completed before and after risk disclosure. Information sharing was assessed post-disclosure. Six-month post-disclosure, genetic risk score participants were more likely than conventional risk score participants to visit a website to learn about CHD (odds ratio [OR], 4.88 [confidence interval (CI), 1.55-19.13]; P=0.01), use the internet for information about how genetic factors affect CHD risk (OR, 2.11 [CI, 1.03-4.47]; P=0.04), access their CHD risk via a patient portal (OR, 2.99 [CI, 1.35-7.04]; P=0.01), and discuss their CHD risk with others (OR, 3.13 [CI, 1.41-7.47]; P=0.01), particularly their siblings (OR, 1.92 [CI, 1.06-3.51]; P=0.03), extended family (OR, 3.8 [CI, 1.37-12.38]; P=0.01), coworkers (OR, 2.42 [CI, 1.09-5.76]; P=0.03), and primary care provider (PCP; OR, 2.00 [CI, 1.08-3.75]; P=0.03). Conclusions - Disclosure of a genetic risk score for CHD increased information seeking and sharing.

Original languageEnglish (US)
Article numbere001613
JournalCirculation: Cardiovascular Genetics
Volume10
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Information Dissemination
Coronary Disease
Myocardial Infarction
Odds Ratio
Confidence Intervals
Genes
Disclosure
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Internet
Siblings
Primary Health Care

Keywords

  • coronary disease
  • electronic health records
  • genetic testing
  • polymorphism, genetic

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing : The MI-GENES Study (Myocardial Infarction Genes). / Brown, Sherry Ann N.; Jouni, Hayan; Marroush, Tariq S.; Kullo, Iftikhar Jan.

In: Circulation: Cardiovascular Genetics, Vol. 10, No. 4, e001613, 01.08.2017.

Research output: Contribution to journalArticle

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abstract = "Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known. We hypothesized that disclosing genetic risk for CHD to individuals influences information seeking and sharing. Methods and Results - The MI-GENES study (Myocardial Infarction Genes) randomized participants (n=203) aged 45 to 65 years who were at intermediate CHD risk based on conventional risk factors and not on statins to receive their conventional risk score alone or also a genetic risk score based on 28 variants. CHD risk was disclosed by a genetic counselor and then discussed with a physician. Surveys assessing information seeking were completed before and after risk disclosure. Information sharing was assessed post-disclosure. Six-month post-disclosure, genetic risk score participants were more likely than conventional risk score participants to visit a website to learn about CHD (odds ratio [OR], 4.88 [confidence interval (CI), 1.55-19.13]; P=0.01), use the internet for information about how genetic factors affect CHD risk (OR, 2.11 [CI, 1.03-4.47]; P=0.04), access their CHD risk via a patient portal (OR, 2.99 [CI, 1.35-7.04]; P=0.01), and discuss their CHD risk with others (OR, 3.13 [CI, 1.41-7.47]; P=0.01), particularly their siblings (OR, 1.92 [CI, 1.06-3.51]; P=0.03), extended family (OR, 3.8 [CI, 1.37-12.38]; P=0.01), coworkers (OR, 2.42 [CI, 1.09-5.76]; P=0.03), and primary care provider (PCP; OR, 2.00 [CI, 1.08-3.75]; P=0.03). Conclusions - Disclosure of a genetic risk score for CHD increased information seeking and sharing.",
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