Effect of diabetes on the induction of ornithine decarboxylase by refeeding

S. Jaime Rozovski, Cheryl A. Conover, Neil B. Ruderman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Refeeding of starved rats that had previously been schedule-fed increased ornithine decarboxylase activity 140-fold in liver and six-fold in skeletal muscle within three hours. In diabetic rats, refeeding caused a smaller increase in enzyme activity in liver and none at all in muscle. When insulin was administered together with food to the diabetic rats, ornithine decarboxylase in muscle increased to levels greater than those observed in refed controls. The activity of the enzyme in liver also increased; however, the increase was still less than that observed in refed control rats. The data indicate that the induction of ornithine decarboxylase in liver and muscle following food ingestion is altered in diabetes. In addition, they suggest that insulin, or a factor dependent on insulin, modulates the activity of ornithine decarboxylase in skeletal muscle.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalLife Sciences
Volume25
Issue number6
DOIs
StatePublished - Aug 6 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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