Abstract
Kidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone®, an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone® vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone® on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystone®. Therefore, this study does not support the efficacy of Cystone® to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types.
Original language | English (US) |
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Pages (from-to) | 863-867 |
Number of pages | 5 |
Journal | Phytomedicine |
Volume | 18 |
Issue number | 10 |
DOIs | |
State | Published - Jul 15 2011 |
Keywords
- Computerized tomography
- Cystone
- Herb
- Kidney calculi
- Nephrolithiasis
- Quantitative CT
- Supersaturation
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine