Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination

Moses Rodriguez, Jawaid Quddus

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Treatment with cyclosporin A, from the time of virus infection, suppressed inflammation and demyelination in the spinal cord of SJL/J or ASW(H-2s) mice persistently infected with Theiler's murine encephalomyelitis virus. Demyelination was not decreased if treatment was given after inflammation was established. The decrease was independent of serum titers of immunoglobulin G to purified viral antigen but did correlate with decreased proliferation of T lymphocytes to virus and myelin antigens. Silica quartz dust, a direct toxin of macrophages, suppressed demyelination and inflammation if begun at time of virus infection. No therapeutic effect was seen with inhibitors of plasminogen activators or other neutral proteases found primarily in macrophages.

Original languageEnglish (US)
Pages (from-to)159-174
Number of pages16
JournalJournal of neuroimmunology
Volume13
Issue number2
DOIs
StatePublished - Dec 1986

Keywords

  • Cyclosporin
  • Demyelination
  • Immunosuppression
  • Multiple sclerosis
  • Theiler's virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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