Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery: A report from the Coronary Artery Surgery Study (CASS) Registry

M. R. Bell, B. J. Gersh, Hartzell V Schaff, David Holmes, L. D. Fisher, E. L. Alderman, W. O. Myers, L. S. Parsons, G. S. Reeder, W. J. Rogers, R. O. Russell, A. Oberman, N. T. Kouchoukos, E. D. Foster, J. A. Sosa, J. T. Doyle, M. F. McKneally, J. B. McIlduff, H. Odabashian

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Abstract

Background. Complete revascularization after coronary artery bypass surgery is a logical goal and improves symptomatic outcome and survival. However, the impact of complete revascularization in patients with three- vessel coronary disease with varying severities of angina and left ventricular dysfunction has not been clearly defined. Methods and Results. The study was performed as a retrospective analysis of 3,372 nonrandomized surgical patients from the Coronary Artery Surgery Study (CASS) Registry who had three-vessel coronary disease. Group 1 (894 patients) had class I or II angina (Canadian Cardiovascular Society criteria) and group 2 (2,478 patients) had class III or IV angina. In group 1, adjusted cumulative 4-year survivals according to the number of vessels bypassed were 85% (one vessel), 94% (two vessels), 96% (three vessels), and 96% (more than three vessels) (log rank, p=0.022). Adjusted event-free survival (death, myocardial infarction, definite angina, or reoperation) was not influenced by the number of vessels bypassed, nor was the anginal status among patients remaining alive after 5 years. In group 2, adjusted cumulative 5-year survivals were 78% (one vessel), 85% (two vessels), 90% (three vessels), and 87% (more than three vessels) (log rank, p=0.074). Adjusted event-free survivals after 6 years were 23% (one vessel), 23% (two vessels), 29% (three vessels), and 31% (more than three vessels) (p=0.025); at 5 years, those with more complete revascularization were more likely to be asymptomatic or free of severe angina. Among group 2 patients with ejection fractions <0.35, 6-year survival was 69% for those with grafts to three or more vessels versus 45% for those with grafts to two vessels (p=0.04). Placing grafts to three or more vessels was independently associated with improved survival and event-free survival in group 2 but not group 1 patients. The case-fatality rates among 529 patients experiencing a myocardial infarction during follow-up was significantly higher for patients with less complete revascularization. Conclusions. Complete revascularization (grafts to three or more vessels) in patients with three-vessel coronary disease appears to most benefit those with severe angina and left ventricular dysfunction.

Original languageEnglish (US)
Pages (from-to)446-457
Number of pages12
JournalCirculation
Volume86
Issue number2
StatePublished - 1992

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Coronary Artery Bypass
Registries
Coronary Vessels
Survival
Disease-Free Survival
Coronary Disease
Transplants
Left Ventricular Dysfunction
Myocardial Infarction
Reoperation
Mortality

Keywords

  • coronary artery bypass
  • coronary disease
  • revascularization, myocardial

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery : A report from the Coronary Artery Surgery Study (CASS) Registry. / Bell, M. R.; Gersh, B. J.; Schaff, Hartzell V; Holmes, David; Fisher, L. D.; Alderman, E. L.; Myers, W. O.; Parsons, L. S.; Reeder, G. S.; Rogers, W. J.; Russell, R. O.; Oberman, A.; Kouchoukos, N. T.; Foster, E. D.; Sosa, J. A.; Doyle, J. T.; McKneally, M. F.; McIlduff, J. B.; Odabashian, H.

In: Circulation, Vol. 86, No. 2, 1992, p. 446-457.

Research output: Contribution to journalArticle

Bell, MR, Gersh, BJ, Schaff, HV, Holmes, D, Fisher, LD, Alderman, EL, Myers, WO, Parsons, LS, Reeder, GS, Rogers, WJ, Russell, RO, Oberman, A, Kouchoukos, NT, Foster, ED, Sosa, JA, Doyle, JT, McKneally, MF, McIlduff, JB & Odabashian, H 1992, 'Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery: A report from the Coronary Artery Surgery Study (CASS) Registry', Circulation, vol. 86, no. 2, pp. 446-457.
Bell, M. R. ; Gersh, B. J. ; Schaff, Hartzell V ; Holmes, David ; Fisher, L. D. ; Alderman, E. L. ; Myers, W. O. ; Parsons, L. S. ; Reeder, G. S. ; Rogers, W. J. ; Russell, R. O. ; Oberman, A. ; Kouchoukos, N. T. ; Foster, E. D. ; Sosa, J. A. ; Doyle, J. T. ; McKneally, M. F. ; McIlduff, J. B. ; Odabashian, H. / Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery : A report from the Coronary Artery Surgery Study (CASS) Registry. In: Circulation. 1992 ; Vol. 86, No. 2. pp. 446-457.
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abstract = "Background. Complete revascularization after coronary artery bypass surgery is a logical goal and improves symptomatic outcome and survival. However, the impact of complete revascularization in patients with three- vessel coronary disease with varying severities of angina and left ventricular dysfunction has not been clearly defined. Methods and Results. The study was performed as a retrospective analysis of 3,372 nonrandomized surgical patients from the Coronary Artery Surgery Study (CASS) Registry who had three-vessel coronary disease. Group 1 (894 patients) had class I or II angina (Canadian Cardiovascular Society criteria) and group 2 (2,478 patients) had class III or IV angina. In group 1, adjusted cumulative 4-year survivals according to the number of vessels bypassed were 85{\%} (one vessel), 94{\%} (two vessels), 96{\%} (three vessels), and 96{\%} (more than three vessels) (log rank, p=0.022). Adjusted event-free survival (death, myocardial infarction, definite angina, or reoperation) was not influenced by the number of vessels bypassed, nor was the anginal status among patients remaining alive after 5 years. In group 2, adjusted cumulative 5-year survivals were 78{\%} (one vessel), 85{\%} (two vessels), 90{\%} (three vessels), and 87{\%} (more than three vessels) (log rank, p=0.074). Adjusted event-free survivals after 6 years were 23{\%} (one vessel), 23{\%} (two vessels), 29{\%} (three vessels), and 31{\%} (more than three vessels) (p=0.025); at 5 years, those with more complete revascularization were more likely to be asymptomatic or free of severe angina. Among group 2 patients with ejection fractions <0.35, 6-year survival was 69{\%} for those with grafts to three or more vessels versus 45{\%} for those with grafts to two vessels (p=0.04). Placing grafts to three or more vessels was independently associated with improved survival and event-free survival in group 2 but not group 1 patients. The case-fatality rates among 529 patients experiencing a myocardial infarction during follow-up was significantly higher for patients with less complete revascularization. Conclusions. Complete revascularization (grafts to three or more vessels) in patients with three-vessel coronary disease appears to most benefit those with severe angina and left ventricular dysfunction.",
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author = "Bell, {M. R.} and Gersh, {B. J.} and Schaff, {Hartzell V} and David Holmes and Fisher, {L. D.} and Alderman, {E. L.} and Myers, {W. O.} and Parsons, {L. S.} and Reeder, {G. S.} and Rogers, {W. J.} and Russell, {R. O.} and A. Oberman and Kouchoukos, {N. T.} and Foster, {E. D.} and Sosa, {J. A.} and Doyle, {J. T.} and McKneally, {M. F.} and McIlduff, {J. B.} and H. Odabashian",
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TY - JOUR

T1 - Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery

T2 - A report from the Coronary Artery Surgery Study (CASS) Registry

AU - Bell, M. R.

AU - Gersh, B. J.

AU - Schaff, Hartzell V

AU - Holmes, David

AU - Fisher, L. D.

AU - Alderman, E. L.

AU - Myers, W. O.

AU - Parsons, L. S.

AU - Reeder, G. S.

AU - Rogers, W. J.

AU - Russell, R. O.

AU - Oberman, A.

AU - Kouchoukos, N. T.

AU - Foster, E. D.

AU - Sosa, J. A.

AU - Doyle, J. T.

AU - McKneally, M. F.

AU - McIlduff, J. B.

AU - Odabashian, H.

PY - 1992

Y1 - 1992

N2 - Background. Complete revascularization after coronary artery bypass surgery is a logical goal and improves symptomatic outcome and survival. However, the impact of complete revascularization in patients with three- vessel coronary disease with varying severities of angina and left ventricular dysfunction has not been clearly defined. Methods and Results. The study was performed as a retrospective analysis of 3,372 nonrandomized surgical patients from the Coronary Artery Surgery Study (CASS) Registry who had three-vessel coronary disease. Group 1 (894 patients) had class I or II angina (Canadian Cardiovascular Society criteria) and group 2 (2,478 patients) had class III or IV angina. In group 1, adjusted cumulative 4-year survivals according to the number of vessels bypassed were 85% (one vessel), 94% (two vessels), 96% (three vessels), and 96% (more than three vessels) (log rank, p=0.022). Adjusted event-free survival (death, myocardial infarction, definite angina, or reoperation) was not influenced by the number of vessels bypassed, nor was the anginal status among patients remaining alive after 5 years. In group 2, adjusted cumulative 5-year survivals were 78% (one vessel), 85% (two vessels), 90% (three vessels), and 87% (more than three vessels) (log rank, p=0.074). Adjusted event-free survivals after 6 years were 23% (one vessel), 23% (two vessels), 29% (three vessels), and 31% (more than three vessels) (p=0.025); at 5 years, those with more complete revascularization were more likely to be asymptomatic or free of severe angina. Among group 2 patients with ejection fractions <0.35, 6-year survival was 69% for those with grafts to three or more vessels versus 45% for those with grafts to two vessels (p=0.04). Placing grafts to three or more vessels was independently associated with improved survival and event-free survival in group 2 but not group 1 patients. The case-fatality rates among 529 patients experiencing a myocardial infarction during follow-up was significantly higher for patients with less complete revascularization. Conclusions. Complete revascularization (grafts to three or more vessels) in patients with three-vessel coronary disease appears to most benefit those with severe angina and left ventricular dysfunction.

AB - Background. Complete revascularization after coronary artery bypass surgery is a logical goal and improves symptomatic outcome and survival. However, the impact of complete revascularization in patients with three- vessel coronary disease with varying severities of angina and left ventricular dysfunction has not been clearly defined. Methods and Results. The study was performed as a retrospective analysis of 3,372 nonrandomized surgical patients from the Coronary Artery Surgery Study (CASS) Registry who had three-vessel coronary disease. Group 1 (894 patients) had class I or II angina (Canadian Cardiovascular Society criteria) and group 2 (2,478 patients) had class III or IV angina. In group 1, adjusted cumulative 4-year survivals according to the number of vessels bypassed were 85% (one vessel), 94% (two vessels), 96% (three vessels), and 96% (more than three vessels) (log rank, p=0.022). Adjusted event-free survival (death, myocardial infarction, definite angina, or reoperation) was not influenced by the number of vessels bypassed, nor was the anginal status among patients remaining alive after 5 years. In group 2, adjusted cumulative 5-year survivals were 78% (one vessel), 85% (two vessels), 90% (three vessels), and 87% (more than three vessels) (log rank, p=0.074). Adjusted event-free survivals after 6 years were 23% (one vessel), 23% (two vessels), 29% (three vessels), and 31% (more than three vessels) (p=0.025); at 5 years, those with more complete revascularization were more likely to be asymptomatic or free of severe angina. Among group 2 patients with ejection fractions <0.35, 6-year survival was 69% for those with grafts to three or more vessels versus 45% for those with grafts to two vessels (p=0.04). Placing grafts to three or more vessels was independently associated with improved survival and event-free survival in group 2 but not group 1 patients. The case-fatality rates among 529 patients experiencing a myocardial infarction during follow-up was significantly higher for patients with less complete revascularization. Conclusions. Complete revascularization (grafts to three or more vessels) in patients with three-vessel coronary disease appears to most benefit those with severe angina and left ventricular dysfunction.

KW - coronary artery bypass

KW - coronary disease

KW - revascularization, myocardial

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