Abstract
Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. Materials and Methods We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group. Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159). Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.
Original language | English (US) |
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Pages (from-to) | 345-351 |
Number of pages | 7 |
Journal | Annals of Gastroenterology |
Volume | 25 |
Issue number | 4 |
State | Published - 2012 |
Keywords
- Extended hepatectomy
- Pringle maneuver
- Remnant liver
- Small-for-size graft
- Split liver transplantation
ASJC Scopus subject areas
- Gastroenterology