Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9

Tomohide Hori, Shinji Uemoto, Feng Chen, Ann Marie T Baine, Lindsay B. Gardner, Toshiyuki Hata, Kagemasa Kuribayashi, Takuma Kato, Kanako Saito, Linan Wang, Mie Torii, Kosuke Endo, Kanta Jobara, Beni Sulistiono, Justin H Nguyen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. Materials and Methods We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group. Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159). Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalAnnals of Gastroenterology
Volume25
Issue number4
StatePublished - 2012

Fingerprint

Cold Ischemia
Matrix Metalloproteinase 9
Portal Hypertension
Reperfusion Injury
Liver Transplantation
Hepatectomy
Transplants
Laparotomy
Liver
Liver Regeneration

Keywords

  • Extended hepatectomy
  • Pringle maneuver
  • Remnant liver
  • Small-for-size graft
  • Split liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9. / Hori, Tomohide; Uemoto, Shinji; Chen, Feng; Baine, Ann Marie T; Gardner, Lindsay B.; Hata, Toshiyuki; Kuribayashi, Kagemasa; Kato, Takuma; Saito, Kanako; Wang, Linan; Torii, Mie; Endo, Kosuke; Jobara, Kanta; Sulistiono, Beni; Nguyen, Justin H.

In: Annals of Gastroenterology, Vol. 25, No. 4, 2012, p. 345-351.

Research output: Contribution to journalArticle

Hori, T, Uemoto, S, Chen, F, Baine, AMT, Gardner, LB, Hata, T, Kuribayashi, K, Kato, T, Saito, K, Wang, L, Torii, M, Endo, K, Jobara, K, Sulistiono, B & Nguyen, JH 2012, 'Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9', Annals of Gastroenterology, vol. 25, no. 4, pp. 345-351.
Hori, Tomohide ; Uemoto, Shinji ; Chen, Feng ; Baine, Ann Marie T ; Gardner, Lindsay B. ; Hata, Toshiyuki ; Kuribayashi, Kagemasa ; Kato, Takuma ; Saito, Kanako ; Wang, Linan ; Torii, Mie ; Endo, Kosuke ; Jobara, Kanta ; Sulistiono, Beni ; Nguyen, Justin H. / Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9. In: Annals of Gastroenterology. 2012 ; Vol. 25, No. 4. pp. 345-351.
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abstract = "Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. Materials and Methods We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100{\%} OLT), partial hepatectomy without the Pringle maneuver (60{\%} hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40{\%} SOLT) were investigated. Four liver samples were collected in each group. Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100{\%} OLT (P = 0.1781) and 60{\%} hepatectomy (P = 0.2367), but it was significantly higher with 40{\%} SOLT compared to that with laparotomy (P = 0.0159). Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.",
keywords = "Extended hepatectomy, Pringle maneuver, Remnant liver, Small-for-size graft, Split liver transplantation",
author = "Tomohide Hori and Shinji Uemoto and Feng Chen and Baine, {Ann Marie T} and Gardner, {Lindsay B.} and Toshiyuki Hata and Kagemasa Kuribayashi and Takuma Kato and Kanako Saito and Linan Wang and Mie Torii and Kosuke Endo and Kanta Jobara and Beni Sulistiono and Nguyen, {Justin H}",
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T1 - Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9

AU - Hori, Tomohide

AU - Uemoto, Shinji

AU - Chen, Feng

AU - Baine, Ann Marie T

AU - Gardner, Lindsay B.

AU - Hata, Toshiyuki

AU - Kuribayashi, Kagemasa

AU - Kato, Takuma

AU - Saito, Kanako

AU - Wang, Linan

AU - Torii, Mie

AU - Endo, Kosuke

AU - Jobara, Kanta

AU - Sulistiono, Beni

AU - Nguyen, Justin H

PY - 2012

Y1 - 2012

N2 - Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. Materials and Methods We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group. Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159). Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.

AB - Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. Materials and Methods We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group. Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159). Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.

KW - Extended hepatectomy

KW - Pringle maneuver

KW - Remnant liver

KW - Small-for-size graft

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