Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients

Garth Powis, Phillip Reece, David L. Ahmann, James N. Ingle

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Cyclophosphamide pharmacolinetics have been studied in 16 female patients with advanced breast cancer. The group included 7 patients who were >20%, ≤30% over ideal body weight and 5 patients who were >30% over ideal body weight. Cyclophosphamide plasma elimination half-lives ranged between 152 and 984 min (mean 457 min), the apparent volume of distribution between 19.1 and 62.31 (mean 36.11), and plasma clearance between 25.9 and 166.6 ml/min (mean 69.5 ml/min). There was a significant positive correlation (r=0.624, P=0.010) between body weight and plasma elimination half-life, and a significant negative correlation between body weight and cyclophosphamide clearance when normalized to body surface area (r=0.578, P=0.019) or normalized to ideal body weight (r=0.531, P=0.0345). the apparent volume of distribution did not correlate with body weight. The results show that cyclophosphamide disposition is altered in patients with increased body weight.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalCancer Chemotherapy and Pharmacology
Volume20
Issue number3
DOIs
StatePublished - Sep 1987

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Pharmacokinetics
Ideal Body Weight
Cyclophosphamide
Body Weight
Breast Neoplasms
Plasmas
Body Surface Area
Half-Life

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Cite this

Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients. / Powis, Garth; Reece, Phillip; Ahmann, David L.; Ingle, James N.

In: Cancer Chemotherapy and Pharmacology, Vol. 20, No. 3, 09.1987, p. 219-222.

Research output: Contribution to journalArticle

Powis, Garth ; Reece, Phillip ; Ahmann, David L. ; Ingle, James N. / Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients. In: Cancer Chemotherapy and Pharmacology. 1987 ; Vol. 20, No. 3. pp. 219-222.
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