Effect of Ascorbic Acid Supplementation on Tissue Ascorbic Acid Status and Nucleic Acid Content of Young and Aged Rats

Muthuvel Jayachandran, Sundararajan Lalithapriya, Chinnakkannu Panneerselvam

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Ascorbic acid has been reported to have corrective influences on the alteration of metabolic processes observed during ageing. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight) for 15, 30, and 60 days on young and aged rats. Organ weight and ascorbic acid content of the liver, spleen, and kidney as well as their deoxyribonucleic acid and ribonucleic acid contents were low in aged rats, although a considerable increase in the values of these parameters was noted after supplementation with ascorbic acid; and for 30 days the magnitude of the increase rose further after supplementation for 60 days. The organ weights and ascorbic acid and nucleic acid contents increased markedly only on prolonged ascorbic acid supplementation (i.e., 60 days) in young rats.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume19
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • ageing
  • ascorbic acid
  • deoxyribonucleic acid
  • ribonucleic acid
  • supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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