Effect of artificial pancreas treatment on peripheral nerve function in diabetes

F. J. Service, J. R. Daube, P. C. O'Brien, Peter J Dyck

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR® Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+3.2 ± 1.4 meters per second, p < 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted sensory examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.

Original languageEnglish (US)
Pages (from-to)1375-1380
Number of pages6
JournalNeurology
Volume31
Issue number11
StatePublished - 1981

Fingerprint

Artificial Pancreas
Peripheral Nerves
Hyperglycemia
Insulin Infusion Systems
Glucose
Neural Conduction
Neurologic Examination
Nervous System
Insulin
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Service, F. J., Daube, J. R., O'Brien, P. C., & Dyck, P. J. (1981). Effect of artificial pancreas treatment on peripheral nerve function in diabetes. Neurology, 31(11), 1375-1380.

Effect of artificial pancreas treatment on peripheral nerve function in diabetes. / Service, F. J.; Daube, J. R.; O'Brien, P. C.; Dyck, Peter J.

In: Neurology, Vol. 31, No. 11, 1981, p. 1375-1380.

Research output: Contribution to journalArticle

Service, FJ, Daube, JR, O'Brien, PC & Dyck, PJ 1981, 'Effect of artificial pancreas treatment on peripheral nerve function in diabetes', Neurology, vol. 31, no. 11, pp. 1375-1380.
Service, F. J. ; Daube, J. R. ; O'Brien, P. C. ; Dyck, Peter J. / Effect of artificial pancreas treatment on peripheral nerve function in diabetes. In: Neurology. 1981 ; Vol. 31, No. 11. pp. 1375-1380.
@article{22214ace98154ce187bacb1e3e0e7031,
title = "Effect of artificial pancreas treatment on peripheral nerve function in diabetes",
abstract = "To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR{\circledR} Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+3.2 ± 1.4 meters per second, p < 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted sensory examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.",
author = "Service, {F. J.} and Daube, {J. R.} and O'Brien, {P. C.} and Dyck, {Peter J}",
year = "1981",
language = "English (US)",
volume = "31",
pages = "1375--1380",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Effect of artificial pancreas treatment on peripheral nerve function in diabetes

AU - Service, F. J.

AU - Daube, J. R.

AU - O'Brien, P. C.

AU - Dyck, Peter J

PY - 1981

Y1 - 1981

N2 - To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR® Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+3.2 ± 1.4 meters per second, p < 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted sensory examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.

AB - To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR® Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+3.2 ± 1.4 meters per second, p < 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted sensory examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.

UR - http://www.scopus.com/inward/record.url?scp=0019813859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019813859&partnerID=8YFLogxK

M3 - Article

C2 - 7031500

AN - SCOPUS:0019813859

VL - 31

SP - 1375

EP - 1380

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 11

ER -