Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man.

R. A. Rizza, M. W. Haymond, J. M. Miles, C. A. Verdonk, P. E. Cryer, J. E. Gerich

Research output: Contribution to journalArticle

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Abstract

Epinephrine (50 ng . kg-1 . min-1) was infused for 120 min in seven normal volunteers alone (combined alpha- and beta-adrenergic stimulation), with propranolol (alpha-adrenergic stimulation), and with propranolol plus phentolamine (alpha-adrenergic blockade superimposed on alpha-adrenergic stimulation). During alpha-adrenergic stimulation, plasma glucose and glucose production increased 32 and 42% less, respectively, than during infusion of epinephrine alone, whereas glucose clearance was suppressed comparably. Plasma insulin decreased during alpha-adrenergic stimulation but increased during infusion of epinephrine alone. Plasma epinephrine was threefold greater during infusion of epinephrine plus propranolol than during infusion of epinephrine alone. When alpha-adrenergic blockade was superimposed on alpha-adrenergic stimulation, the increases in plasma glucose and glucose production as well as the decreases in plasma insulin and glucose clearance observed during alpha-adrenergic stimulation were virtually abolished, whereas plasma epinephrine levels were unaltered. These results indicate that in man epinephrine can cause hyperglycemia via both alpha- and beta-adrenergic stimulation of glucose production and suppression of glucose clearance, either directly or indirectly. alpha-Adrenergic effects on glucose production and clearance may be mediated by inhibition of insulin secretion.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume238
Issue number5
StatePublished - May 1980

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Adrenergic Agents
Epinephrine
Glucose
Propranolol
Insulin
Phentolamine
Hyperglycemia
Healthy Volunteers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rizza, R. A., Haymond, M. W., Miles, J. M., Verdonk, C. A., Cryer, P. E., & Gerich, J. E. (1980). Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. The American journal of physiology, 238(5).

Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. / Rizza, R. A.; Haymond, M. W.; Miles, J. M.; Verdonk, C. A.; Cryer, P. E.; Gerich, J. E.

In: The American journal of physiology, Vol. 238, No. 5, 05.1980.

Research output: Contribution to journalArticle

Rizza, RA, Haymond, MW, Miles, JM, Verdonk, CA, Cryer, PE & Gerich, JE 1980, 'Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man.', The American journal of physiology, vol. 238, no. 5.
Rizza RA, Haymond MW, Miles JM, Verdonk CA, Cryer PE, Gerich JE. Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. The American journal of physiology. 1980 May;238(5).
Rizza, R. A. ; Haymond, M. W. ; Miles, J. M. ; Verdonk, C. A. ; Cryer, P. E. ; Gerich, J. E. / Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. In: The American journal of physiology. 1980 ; Vol. 238, No. 5.
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