Abstract
Effect of acupuncture on the expressions of nitric oxide synthase (NOS) and neuronal NOS (nNOS) in the cerebral cortex of streptozotocin (STZ)-induced diabetic rats was investigated. Animals were divided into four groups; the control group, the nondiabetic and acupunctured group, the STZ-induced-diabetes group, and the STZ-induced diabetic and acupunctured group. To produce the diabetic animal model, a single intraperitoneal injection of STZ (50 mg/kg) was given to each animal; animals of the nondiabetic groups received equivalent amounts of normal saline, also via intraperitoneal injection. From the results, acupuncture was shown to increase the numbers of nicotinamide adenine dinucleotide phosphate-diaphorase-positive and nNOS-positive neurons in STZ-induced diabetic rats. From the present study, it may be suggested that acupuncture modulates NOS and nNOS expressions in the cerebral cortex under diabetic conditions.
Original language | English (US) |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Acupuncture and Electro-Therapeutics Research |
Volume | 28 |
Issue number | 1-2 |
DOIs | |
State | Published - 2003 |
Keywords
- Acupuncture
- Cerebral cortex
- Diabetes
- Neuronal nitric oxide synthase
- Nicotinamide adenine dinucleotide phosphate-diaphorase
- Streptozotocin
ASJC Scopus subject areas
- General Neuroscience
- Complementary and alternative medicine
- Anesthesiology and Pain Medicine