Effect of acupuncture on nitric oxide synthase expression in cerebral cortex of streptozotocin-induced diabetic rats

Mi Hyeon Jang, Min Chul Shin, Young Pyo Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Effect of acupuncture on the expressions of nitric oxide synthase (NOS) and neuronal NOS (nNOS) in the cerebral cortex of streptozotocin (STZ)-induced diabetic rats was investigated. Animals were divided into four groups; the control group, the nondiabetic and acupunctured group, the STZ-induced-diabetes group, and the STZ-induced diabetic and acupunctured group. To produce the diabetic animal model, a single intraperitoneal injection of STZ (50 mg/kg) was given to each animal; animals of the nondiabetic groups received equivalent amounts of normal saline, also via intraperitoneal injection. From the results, acupuncture was shown to increase the numbers of nicotinamide adenine dinucleotide phosphate-diaphorase-positive and nNOS-positive neurons in STZ-induced diabetic rats. From the present study, it may be suggested that acupuncture modulates NOS and nNOS expressions in the cerebral cortex under diabetic conditions.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalAcupuncture and Electro-Therapeutics Research
Volume28
Issue number1-2
DOIs
StatePublished - Jan 1 2003

Keywords

  • Acupuncture
  • Cerebral cortex
  • Diabetes
  • Neuronal nitric oxide synthase
  • Nicotinamide adenine dinucleotide phosphate-diaphorase
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Complementary and alternative medicine
  • Anesthesiology and Pain Medicine

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