Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs

Shu Long Zhang, Ying Xue Dong, Peng Jiang, Lian Jun Gao, Yong-Mei Cha, Douglas L Packer, Yun Long Xia, Xiao Meng Yin, Dong Chang, Yan Zong Yang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Clinical observations have shown that the complex fractionated atrial electrogram (CFAE) associates with ganglionated plexus activity in the cardiac autonomic nervous system. This study aimed to investigate the impact of CFAE ablation on vagal modulation to atria and vulnerability to develop atrial fibrillation (AF). Methods Ten adult mongrel dogs were involved. Cervical sympathovagal trunks were decentralized and sympathetic effects were blocked. CFAE was color tagged on the atrial 3-dimensional image and ablated during AF induced by S1S2 programmed stimulation plus sympathovagal trunk stimulation. Atrial effective refractory period (ERP) and vulnerability window (VW) of AF were measured on baseline and at vagal stimulation at 4 atrium sites. Serial tissue sections from ablative and control specimens received hematoxylin and eosin staining for microscopic examination. Results Most CFAE areas were localized at the right superior pulmonary quadrant, distal coronary sinus (CSd) quadrant, and proximal coronary sinus (CSp) quadrant (21.74%, separately). Sinus rhythm cycle length (SCL) shortening did not decrease significantly after ablation at the sites, including right atrial appendage, left atrial appendage, CSd, and CSp (P >0.05). ERP shortening during vagal stimulation significantly decreased after ablation (P <0.01); the VW to vagal stimulation significantly decreased after ablation (P <0.05). The architecture of individual ganglia altered after ablation. Conclusions CFAE has an autonomic basis in dogs. The decreased SCL and ERP shortening to vagal stimulation after CFAE ablation demonstrate that CFAE ablation attenuates vagal modulation to the atria, thereby suppressing AF mediated by enhanced vagal activity. CFAE ablation could suppress AF mediated by enhanced vagal activity.

Original languageEnglish (US)
Pages (from-to)3288-3292
Number of pages5
JournalChinese Medical Journal
Volume123
Issue number22
DOIs
StatePublished - Nov 20 2010

Fingerprint

Cardiac Electrophysiologic Techniques
Dogs
Atrial Fibrillation
Atrial Appendage
Coronary Sinus
Autonomic Nervous System
Hematoxylin
Eosine Yellowish-(YS)
Ganglia
Color
Staining and Labeling
Lung

Keywords

  • Atrial fibrillation
  • Autonomic nervous system
  • Catheter ablation
  • Complex fractionated atrial electrogram
  • Vagus nerve

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs. / Zhang, Shu Long; Dong, Ying Xue; Jiang, Peng; Gao, Lian Jun; Cha, Yong-Mei; Packer, Douglas L; Xia, Yun Long; Yin, Xiao Meng; Chang, Dong; Yang, Yan Zong.

In: Chinese Medical Journal, Vol. 123, No. 22, 20.11.2010, p. 3288-3292.

Research output: Contribution to journalArticle

Zhang, Shu Long ; Dong, Ying Xue ; Jiang, Peng ; Gao, Lian Jun ; Cha, Yong-Mei ; Packer, Douglas L ; Xia, Yun Long ; Yin, Xiao Meng ; Chang, Dong ; Yang, Yan Zong. / Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs. In: Chinese Medical Journal. 2010 ; Vol. 123, No. 22. pp. 3288-3292.
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abstract = "Background Clinical observations have shown that the complex fractionated atrial electrogram (CFAE) associates with ganglionated plexus activity in the cardiac autonomic nervous system. This study aimed to investigate the impact of CFAE ablation on vagal modulation to atria and vulnerability to develop atrial fibrillation (AF). Methods Ten adult mongrel dogs were involved. Cervical sympathovagal trunks were decentralized and sympathetic effects were blocked. CFAE was color tagged on the atrial 3-dimensional image and ablated during AF induced by S1S2 programmed stimulation plus sympathovagal trunk stimulation. Atrial effective refractory period (ERP) and vulnerability window (VW) of AF were measured on baseline and at vagal stimulation at 4 atrium sites. Serial tissue sections from ablative and control specimens received hematoxylin and eosin staining for microscopic examination. Results Most CFAE areas were localized at the right superior pulmonary quadrant, distal coronary sinus (CSd) quadrant, and proximal coronary sinus (CSp) quadrant (21.74{\%}, separately). Sinus rhythm cycle length (SCL) shortening did not decrease significantly after ablation at the sites, including right atrial appendage, left atrial appendage, CSd, and CSp (P >0.05). ERP shortening during vagal stimulation significantly decreased after ablation (P <0.01); the VW to vagal stimulation significantly decreased after ablation (P <0.05). The architecture of individual ganglia altered after ablation. Conclusions CFAE has an autonomic basis in dogs. The decreased SCL and ERP shortening to vagal stimulation after CFAE ablation demonstrate that CFAE ablation attenuates vagal modulation to the atria, thereby suppressing AF mediated by enhanced vagal activity. CFAE ablation could suppress AF mediated by enhanced vagal activity.",
keywords = "Atrial fibrillation, Autonomic nervous system, Catheter ablation, Complex fractionated atrial electrogram, Vagus nerve",
author = "Zhang, {Shu Long} and Dong, {Ying Xue} and Peng Jiang and Gao, {Lian Jun} and Yong-Mei Cha and Packer, {Douglas L} and Xia, {Yun Long} and Yin, {Xiao Meng} and Dong Chang and Yang, {Yan Zong}",
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T1 - Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs

AU - Zhang, Shu Long

AU - Dong, Ying Xue

AU - Jiang, Peng

AU - Gao, Lian Jun

AU - Cha, Yong-Mei

AU - Packer, Douglas L

AU - Xia, Yun Long

AU - Yin, Xiao Meng

AU - Chang, Dong

AU - Yang, Yan Zong

PY - 2010/11/20

Y1 - 2010/11/20

N2 - Background Clinical observations have shown that the complex fractionated atrial electrogram (CFAE) associates with ganglionated plexus activity in the cardiac autonomic nervous system. This study aimed to investigate the impact of CFAE ablation on vagal modulation to atria and vulnerability to develop atrial fibrillation (AF). Methods Ten adult mongrel dogs were involved. Cervical sympathovagal trunks were decentralized and sympathetic effects were blocked. CFAE was color tagged on the atrial 3-dimensional image and ablated during AF induced by S1S2 programmed stimulation plus sympathovagal trunk stimulation. Atrial effective refractory period (ERP) and vulnerability window (VW) of AF were measured on baseline and at vagal stimulation at 4 atrium sites. Serial tissue sections from ablative and control specimens received hematoxylin and eosin staining for microscopic examination. Results Most CFAE areas were localized at the right superior pulmonary quadrant, distal coronary sinus (CSd) quadrant, and proximal coronary sinus (CSp) quadrant (21.74%, separately). Sinus rhythm cycle length (SCL) shortening did not decrease significantly after ablation at the sites, including right atrial appendage, left atrial appendage, CSd, and CSp (P >0.05). ERP shortening during vagal stimulation significantly decreased after ablation (P <0.01); the VW to vagal stimulation significantly decreased after ablation (P <0.05). The architecture of individual ganglia altered after ablation. Conclusions CFAE has an autonomic basis in dogs. The decreased SCL and ERP shortening to vagal stimulation after CFAE ablation demonstrate that CFAE ablation attenuates vagal modulation to the atria, thereby suppressing AF mediated by enhanced vagal activity. CFAE ablation could suppress AF mediated by enhanced vagal activity.

AB - Background Clinical observations have shown that the complex fractionated atrial electrogram (CFAE) associates with ganglionated plexus activity in the cardiac autonomic nervous system. This study aimed to investigate the impact of CFAE ablation on vagal modulation to atria and vulnerability to develop atrial fibrillation (AF). Methods Ten adult mongrel dogs were involved. Cervical sympathovagal trunks were decentralized and sympathetic effects were blocked. CFAE was color tagged on the atrial 3-dimensional image and ablated during AF induced by S1S2 programmed stimulation plus sympathovagal trunk stimulation. Atrial effective refractory period (ERP) and vulnerability window (VW) of AF were measured on baseline and at vagal stimulation at 4 atrium sites. Serial tissue sections from ablative and control specimens received hematoxylin and eosin staining for microscopic examination. Results Most CFAE areas were localized at the right superior pulmonary quadrant, distal coronary sinus (CSd) quadrant, and proximal coronary sinus (CSp) quadrant (21.74%, separately). Sinus rhythm cycle length (SCL) shortening did not decrease significantly after ablation at the sites, including right atrial appendage, left atrial appendage, CSd, and CSp (P >0.05). ERP shortening during vagal stimulation significantly decreased after ablation (P <0.01); the VW to vagal stimulation significantly decreased after ablation (P <0.05). The architecture of individual ganglia altered after ablation. Conclusions CFAE has an autonomic basis in dogs. The decreased SCL and ERP shortening to vagal stimulation after CFAE ablation demonstrate that CFAE ablation attenuates vagal modulation to the atria, thereby suppressing AF mediated by enhanced vagal activity. CFAE ablation could suppress AF mediated by enhanced vagal activity.

KW - Atrial fibrillation

KW - Autonomic nervous system

KW - Catheter ablation

KW - Complex fractionated atrial electrogram

KW - Vagus nerve

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