Effect of a sulfonylurea and insulin on energy expenditure in type II diabetes mellitus

S. Welle, K Sreekumaran Nair, D. Lockwood

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Previous studies demonstrated that administration of insulin and oral hypoglycemic agents tends to produce weight gain in type II diabetic patients. The goal of this study was to determine the potential contribution of changes in metabolic rate and urinary glucose excretion to changes in energy balance associated with treatment with glyburide and insulin. Six obese type II diabetic patients (52-61 yr old; 123-214% of ideal weight) were fed a weight-maintaining diet of fixed composition and caloric content in a Clinical Research Center. The mean fasting plasma glucose concentrations were 10.7 ± 1.3 (± SE) mmol/L before treatment, 7.9 ± 1.4 mmol/L at the end of 2 weeks of glyburide treatment, and 5.2 ± 0.3 mmol/L at the end of 2 weeks of insulin treatment. Urinary glucose excretion decreased from 48 ± 19 g/day before treatment to 20 ± 9 g/day at the end of glyburide treatment and 2 ± 1 g/day at the end of insulin treatment. Neither treatment affected mean postabsorptive resting metabolic rate (untreated 4.86 ± 0.50 kJ/min; glyburide-treated, 4.63 ± 0.45 kJ/min; insulin-treated, 4.70 ± 0.46 kJ/min) or postprandial restig metabolic rate (untreated, 5.71 ± 0.55 kJ/min; glyburide-treated, 5.60 ± 0.39 kJ/min; insulin-treated, 5.70 ± 0.51 kJ/min). However, the two patients with the largest decreases in urinary glucose excretion also had decreases in energy expenditure. These data indicate that many obese type II diabetic patients could have significant weight gain from reduced energy losses alone.

Original languageEnglish (US)
Pages (from-to)593-597
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume66
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Medical problems
Glyburide
Type 2 Diabetes Mellitus
Energy Metabolism
Insulin
Glucose
Therapeutics
Weight Gain
Nutrition
Energy balance
Hypoglycemic Agents
Weights and Measures
Basal Metabolism
Energy dissipation
Oral Administration
Plasmas
Fasting
Diet
Chemical analysis
Research

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of a sulfonylurea and insulin on energy expenditure in type II diabetes mellitus. / Welle, S.; Nair, K Sreekumaran; Lockwood, D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 66, No. 3, 1988, p. 593-597.

Research output: Contribution to journalArticle

@article{7c1b9ce2c09d459f9ec41c8f4d49d2cc,
title = "Effect of a sulfonylurea and insulin on energy expenditure in type II diabetes mellitus",
abstract = "Previous studies demonstrated that administration of insulin and oral hypoglycemic agents tends to produce weight gain in type II diabetic patients. The goal of this study was to determine the potential contribution of changes in metabolic rate and urinary glucose excretion to changes in energy balance associated with treatment with glyburide and insulin. Six obese type II diabetic patients (52-61 yr old; 123-214{\%} of ideal weight) were fed a weight-maintaining diet of fixed composition and caloric content in a Clinical Research Center. The mean fasting plasma glucose concentrations were 10.7 ± 1.3 (± SE) mmol/L before treatment, 7.9 ± 1.4 mmol/L at the end of 2 weeks of glyburide treatment, and 5.2 ± 0.3 mmol/L at the end of 2 weeks of insulin treatment. Urinary glucose excretion decreased from 48 ± 19 g/day before treatment to 20 ± 9 g/day at the end of glyburide treatment and 2 ± 1 g/day at the end of insulin treatment. Neither treatment affected mean postabsorptive resting metabolic rate (untreated 4.86 ± 0.50 kJ/min; glyburide-treated, 4.63 ± 0.45 kJ/min; insulin-treated, 4.70 ± 0.46 kJ/min) or postprandial restig metabolic rate (untreated, 5.71 ± 0.55 kJ/min; glyburide-treated, 5.60 ± 0.39 kJ/min; insulin-treated, 5.70 ± 0.51 kJ/min). However, the two patients with the largest decreases in urinary glucose excretion also had decreases in energy expenditure. These data indicate that many obese type II diabetic patients could have significant weight gain from reduced energy losses alone.",
author = "S. Welle and Nair, {K Sreekumaran} and D. Lockwood",
year = "1988",
language = "English (US)",
volume = "66",
pages = "593--597",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Effect of a sulfonylurea and insulin on energy expenditure in type II diabetes mellitus

AU - Welle, S.

AU - Nair, K Sreekumaran

AU - Lockwood, D.

PY - 1988

Y1 - 1988

N2 - Previous studies demonstrated that administration of insulin and oral hypoglycemic agents tends to produce weight gain in type II diabetic patients. The goal of this study was to determine the potential contribution of changes in metabolic rate and urinary glucose excretion to changes in energy balance associated with treatment with glyburide and insulin. Six obese type II diabetic patients (52-61 yr old; 123-214% of ideal weight) were fed a weight-maintaining diet of fixed composition and caloric content in a Clinical Research Center. The mean fasting plasma glucose concentrations were 10.7 ± 1.3 (± SE) mmol/L before treatment, 7.9 ± 1.4 mmol/L at the end of 2 weeks of glyburide treatment, and 5.2 ± 0.3 mmol/L at the end of 2 weeks of insulin treatment. Urinary glucose excretion decreased from 48 ± 19 g/day before treatment to 20 ± 9 g/day at the end of glyburide treatment and 2 ± 1 g/day at the end of insulin treatment. Neither treatment affected mean postabsorptive resting metabolic rate (untreated 4.86 ± 0.50 kJ/min; glyburide-treated, 4.63 ± 0.45 kJ/min; insulin-treated, 4.70 ± 0.46 kJ/min) or postprandial restig metabolic rate (untreated, 5.71 ± 0.55 kJ/min; glyburide-treated, 5.60 ± 0.39 kJ/min; insulin-treated, 5.70 ± 0.51 kJ/min). However, the two patients with the largest decreases in urinary glucose excretion also had decreases in energy expenditure. These data indicate that many obese type II diabetic patients could have significant weight gain from reduced energy losses alone.

AB - Previous studies demonstrated that administration of insulin and oral hypoglycemic agents tends to produce weight gain in type II diabetic patients. The goal of this study was to determine the potential contribution of changes in metabolic rate and urinary glucose excretion to changes in energy balance associated with treatment with glyburide and insulin. Six obese type II diabetic patients (52-61 yr old; 123-214% of ideal weight) were fed a weight-maintaining diet of fixed composition and caloric content in a Clinical Research Center. The mean fasting plasma glucose concentrations were 10.7 ± 1.3 (± SE) mmol/L before treatment, 7.9 ± 1.4 mmol/L at the end of 2 weeks of glyburide treatment, and 5.2 ± 0.3 mmol/L at the end of 2 weeks of insulin treatment. Urinary glucose excretion decreased from 48 ± 19 g/day before treatment to 20 ± 9 g/day at the end of glyburide treatment and 2 ± 1 g/day at the end of insulin treatment. Neither treatment affected mean postabsorptive resting metabolic rate (untreated 4.86 ± 0.50 kJ/min; glyburide-treated, 4.63 ± 0.45 kJ/min; insulin-treated, 4.70 ± 0.46 kJ/min) or postprandial restig metabolic rate (untreated, 5.71 ± 0.55 kJ/min; glyburide-treated, 5.60 ± 0.39 kJ/min; insulin-treated, 5.70 ± 0.51 kJ/min). However, the two patients with the largest decreases in urinary glucose excretion also had decreases in energy expenditure. These data indicate that many obese type II diabetic patients could have significant weight gain from reduced energy losses alone.

UR - http://www.scopus.com/inward/record.url?scp=0023872859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023872859&partnerID=8YFLogxK

M3 - Article

C2 - 3127418

AN - SCOPUS:0023872859

VL - 66

SP - 593

EP - 597

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -