Effect of α-adrenergic stimulation and its blockade on glucose turnover in man

R. A. Rizza, M. W. Haymond, J. M. Miles

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Epinephrine (50 ng/kg-1/min-1) was infused for 120 min in seven normal volunteers alone (combined α- and β-adrenergic stimulation), with propranolol (α-adrenergic stimulation), and with propranolol plus phentolamine (α-adrenergic blockade superimposed on α-adrenergic stimulation). During α-adrenergic stimulation, plasma glucose and glucose production increased 32 and 42% less, respectively, than during infusion of epinephrine alone, whereas glucose clearance was suppressed comparably. Plasma insulin decreased during α-adrenergic stimulation but increase during infusion of epinephrine plus propranolol than during infusion of epinephrine alone. When α-adrenergic blockade was superimposed on α-adrenergic stimulation, the increases in plasma glucose and glucose production as well as the decreases in plasma insulin and glucose clearance observed during α-adrenergic stimulation were virtually abolished, whereas plasma epinephrine levels were unaltered. These results indicated that in man epinephrine can cause hyperglycemia via both α- and β-adrenergic stimulation of glucose production and suppression of glucose clearance, either directly or indirectly. α-Adrenergic effects on glucose production and clearance may be mediated by inhibition of insulin secretion.

Original languageEnglish (US)
Pages (from-to)E467-E472
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume1
Issue number5
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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