E/e' ratio is a strong prognostic predictor of mortality in patients with non-valvular atrial fibrillation with preserved left ventricular systolic function

Sung Ji Park, Sang Chol Lee, Shin Yi Jang, Sung A. Chang, Jin Oh Choi, Seung Woo Park, Jae K. Oh

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: The purpose of this study was to investigate the prognostic values of the E/e' ratio and other echocardiographic and clinical parameters in patients with non-valvular atrial fibrillation (AF) with preserved left ventricular (LV) systolic function. Methods and Results: A total of 488 patients (322 men, age: 66±11 years) with non-valvular AF with preserved LV systolic function (LV ejection fraction >50%) were included. The E and e' velocities were measured in 5 consecutive heart beats and averaged. Mean follow-up duration after enrollment was 17.7±5.3 months. All-cause deaths occurred in 45 patients (cardiovascular deaths: n=29). There were significant differences in age (65.6±11.3 vs. 71.5±9.1, P<0.001) and hemoglobin concentration (13.6±2.9 vs. 11.5±3.4 g/dl, P<0.0001) between the deceased group and the survivors. E/e' ratio in the deceased group was significantly higher than that in the survivors (17.67±3.39 vs. 10.8±3.30, P<0.001). Survival analysis showed that a high E/e' ratio (>15.0) represents a poorer prognosis (P<0.001 by Log-Rank test) than an E/e' ratio of 15 and below. Multivariate analysis identified 2 significant variables that were predictive of all-cause deaths: hemoglobin (hazard ratio (HR)=0.806, 95% confidence interval (CI)=0.733-0.886, P<0.0001), and E/e' >15 (HR=3.064, 95%CI=1.38-6.804, P=0.006). Conclusions: E/e' ratio is a useful independent prognostic parameter for predicting mortality in patients with AF with preserved LV systolic function.

Original languageEnglish (US)
Pages (from-to)2350-2356
Number of pages7
JournalCirculation Journal
Volume75
Issue number10
DOIs
StatePublished - Oct 1 2011

Keywords

  • Atrial fibrillation
  • Echocardiography
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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