Ectopic low-grade adrenocortical carcinoma in the spinal region: Immunohistochemical and molecular cytogenetic studyof a pediatric case

Fausto J. Rodriguez, Bernd W. Scheithauer, Lori A. Erickson, Robert B. Jenkins, Caterina Giannini

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection. The tumor in both resections had increased mitotic activity (5/10 high power fields) and MIB-1 labeling indices of 23% and 33% at initial resection and recurrence, respectively. Both tumors demonstrated gains of chromosomes 5 and 12 by interphase cytogenetics, whereas insulin growth factor 2 was identified in the recurrent tumor by immunohistochemistry. This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume33
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Adrenocortical tumor
  • Ectopic adrenal
  • FISH
  • Immunohistochemistry
  • Nervous system
  • Spinal cord

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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