Ectopic low-grade adrenocortical carcinoma in the spinal region: Immunohistochemical and molecular cytogenetic studyof a pediatric case

Fausto J. Rodriguez, Bernd W. Scheithauer, Lori A. Erickson, Robert Brian Jenkins, Caterina Giannini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection. The tumor in both resections had increased mitotic activity (5/10 high power fields) and MIB-1 labeling indices of 23% and 33% at initial resection and recurrence, respectively. Both tumors demonstrated gains of chromosomes 5 and 12 by interphase cytogenetics, whereas insulin growth factor 2 was identified in the recurrent tumor by immunohistochemistry. This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume33
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Adrenocortical Carcinoma
Cytogenetics
Pediatrics
Neoplasms
Nervous System Neoplasms
Lumbosacral Region
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 5
Spinal Nerve Roots
Interphase
Nervous System
Intercellular Signaling Peptides and Proteins
Immunohistochemistry
Insulin
Recurrence

Keywords

  • Adrenocortical tumor
  • Ectopic adrenal
  • FISH
  • Immunohistochemistry
  • Nervous system
  • Spinal cord

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Ectopic low-grade adrenocortical carcinoma in the spinal region : Immunohistochemical and molecular cytogenetic studyof a pediatric case. / Rodriguez, Fausto J.; Scheithauer, Bernd W.; Erickson, Lori A.; Jenkins, Robert Brian; Giannini, Caterina.

In: American Journal of Surgical Pathology, Vol. 33, No. 1, 01.2009, p. 142-148.

Research output: Contribution to journalArticle

@article{5557a6670dc84efdb8bb81d2f48a2842,
title = "Ectopic low-grade adrenocortical carcinoma in the spinal region: Immunohistochemical and molecular cytogenetic studyof a pediatric case",
abstract = "Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection. The tumor in both resections had increased mitotic activity (5/10 high power fields) and MIB-1 labeling indices of 23{\%} and 33{\%} at initial resection and recurrence, respectively. Both tumors demonstrated gains of chromosomes 5 and 12 by interphase cytogenetics, whereas insulin growth factor 2 was identified in the recurrent tumor by immunohistochemistry. This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma.",
keywords = "Adrenocortical tumor, Ectopic adrenal, FISH, Immunohistochemistry, Nervous system, Spinal cord",
author = "Rodriguez, {Fausto J.} and Scheithauer, {Bernd W.} and Erickson, {Lori A.} and Jenkins, {Robert Brian} and Caterina Giannini",
year = "2009",
month = "1",
doi = "10.1097/PAS.0b013e318180deda",
language = "English (US)",
volume = "33",
pages = "142--148",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Ectopic low-grade adrenocortical carcinoma in the spinal region

T2 - Immunohistochemical and molecular cytogenetic studyof a pediatric case

AU - Rodriguez, Fausto J.

AU - Scheithauer, Bernd W.

AU - Erickson, Lori A.

AU - Jenkins, Robert Brian

AU - Giannini, Caterina

PY - 2009/1

Y1 - 2009/1

N2 - Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection. The tumor in both resections had increased mitotic activity (5/10 high power fields) and MIB-1 labeling indices of 23% and 33% at initial resection and recurrence, respectively. Both tumors demonstrated gains of chromosomes 5 and 12 by interphase cytogenetics, whereas insulin growth factor 2 was identified in the recurrent tumor by immunohistochemistry. This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma.

AB - Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection. The tumor in both resections had increased mitotic activity (5/10 high power fields) and MIB-1 labeling indices of 23% and 33% at initial resection and recurrence, respectively. Both tumors demonstrated gains of chromosomes 5 and 12 by interphase cytogenetics, whereas insulin growth factor 2 was identified in the recurrent tumor by immunohistochemistry. This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma.

KW - Adrenocortical tumor

KW - Ectopic adrenal

KW - FISH

KW - Immunohistochemistry

KW - Nervous system

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=59149100533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59149100533&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e318180deda

DO - 10.1097/PAS.0b013e318180deda

M3 - Article

C2 - 18941403

AN - SCOPUS:59149100533

VL - 33

SP - 142

EP - 148

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 1

ER -