Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients

R. A. Nishimura, M. D. McGoon, C. Shub, Fletcher A Jr. Miller, D. M. Ilstrup, A. J. Tajik

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Abstract

We determined the long-term prognosis for patients with mitral-valve prolapse documented by echocardiography by following 237 minimally symptomatic or asymptomatic patients for a mean of 6.2 years (range, 1 to 10.4). The actuarial eight-year probability of survival was 88 per cent, which is not significantly different from that for a matched control population. An initial left ventricular diastolic dimension exceeding 60 mm was the best echocardiographic predictor of the subsequent need for mitral-valve replacement (17 patients). Of the 97 patients with redundant mitral-valve leaflets identified echocardiographically, 10 (10.3 per cent) had sudden death, infective endocarditis, or a cerebral embolic event; in contrast, of the 140 patients with nonredundant valves, only 1 (0.7 per cent) had such complications (P < 0.001). Most patients with echocardiographic evidence of mitral-valve prolapse have a benign course, but subsets at high risk for the development of progressive mitral regurgitation, sudden death, cerebral embolic events, or infective endocarditis can be identified by echocardiography.

Original languageEnglish (US)
Pages (from-to)1305-1309
Number of pages5
JournalNew England Journal of Medicine
Volume313
Issue number21
StatePublished - 1985

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Mitral Valve Prolapse
Sudden Death
Endocarditis
Mitral Valve
Echocardiography
Mitral Valve Insufficiency
Survival
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nishimura, R. A., McGoon, M. D., Shub, C., Miller, F. A. J., Ilstrup, D. M., & Tajik, A. J. (1985). Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients. New England Journal of Medicine, 313(21), 1305-1309.

Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients. / Nishimura, R. A.; McGoon, M. D.; Shub, C.; Miller, Fletcher A Jr.; Ilstrup, D. M.; Tajik, A. J.

In: New England Journal of Medicine, Vol. 313, No. 21, 1985, p. 1305-1309.

Research output: Contribution to journalArticle

Nishimura, RA, McGoon, MD, Shub, C, Miller, FAJ, Ilstrup, DM & Tajik, AJ 1985, 'Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients', New England Journal of Medicine, vol. 313, no. 21, pp. 1305-1309.
Nishimura, R. A. ; McGoon, M. D. ; Shub, C. ; Miller, Fletcher A Jr. ; Ilstrup, D. M. ; Tajik, A. J. / Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients. In: New England Journal of Medicine. 1985 ; Vol. 313, No. 21. pp. 1305-1309.
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