Echocardiographic visualization of acute myocardial ischemia-In vitro study

Krishnaswamy Chandrasekaran, James F Greenleaf, Brent S. Robinson, William D. Edwards, James B. Seward, A. Jamil Tajik

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To evaluate whether myocardial texture changes resulting from acute ischemia can be visualized with satisfactory spatial resolution, short axis compound echo images (CEI) (B-scan) were obtained from 12 excised canine hearts in vitro. Seven had myocardial ischemia produced by open chest ligation of the left anterior descending coronary artery (LAD) for 15-30 min prior to excision. The CEI were constructed by compounding 60 simple linear B-scans. Hearts were sectioned after scanning, and gross morphological changes were recorded. Microscopic comparison between grossly abnormal and normal regions were recorded. The CEI from the ischemic group revealed altered myocardial texture seen as bright coarsely granular echoes in the regions normally perfused by the ligated LAD artery. Corresponding anatomic sections revealed increased redness in these regions. Microscopically these regions revealed interstitial and intercellular edema as compared to the normal regions. Acute myocardial ischemia can be visualized in CEI and these regions have significantly increased backscatter, decreased attenuation, and decreased speed of ultrasound relative to normal regions in the same hearts. Myocardial edema is probably responsible for these changes.

Original languageEnglish (US)
Pages (from-to)785-793
Number of pages9
JournalUltrasound in Medicine and Biology
Volume12
Issue number10
DOIs
StatePublished - 1986

Fingerprint

ischemia
Myocardial Ischemia
echoes
Edema
edema
arteries
textures
Ligation
Canidae
Coronary Vessels
Thorax
Ischemia
Arteries
compounding
chest
interstitials
spatial resolution
attenuation
In Vitro Techniques
scanning

Keywords

  • 2D echo texture of ischemic myocardium
  • Myocardial ischemia
  • Ultrasound tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Echocardiographic visualization of acute myocardial ischemia-In vitro study. / Chandrasekaran, Krishnaswamy; Greenleaf, James F; Robinson, Brent S.; Edwards, William D.; Seward, James B.; Tajik, A. Jamil.

In: Ultrasound in Medicine and Biology, Vol. 12, No. 10, 1986, p. 785-793.

Research output: Contribution to journalArticle

Chandrasekaran, Krishnaswamy ; Greenleaf, James F ; Robinson, Brent S. ; Edwards, William D. ; Seward, James B. ; Tajik, A. Jamil. / Echocardiographic visualization of acute myocardial ischemia-In vitro study. In: Ultrasound in Medicine and Biology. 1986 ; Vol. 12, No. 10. pp. 785-793.
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