Echocardiographic visualization of acute myocardial ischemia-In vitro study

Krishnaswamy Chandrasekaran, James F. Greenleaf, Brent S. Robinson, William D. Edwards, James B. Seward, A. Jamil Tajik

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

To evaluate whether myocardial texture changes resulting from acute ischemia can be visualized with satisfactory spatial resolution, short axis compound echo images (CEI) (B-scan) were obtained from 12 excised canine hearts in vitro. Seven had myocardial ischemia produced by open chest ligation of the left anterior descending coronary artery (LAD) for 15-30 min prior to excision. The CEI were constructed by compounding 60 simple linear B-scans. Hearts were sectioned after scanning, and gross morphological changes were recorded. Microscopic comparison between grossly abnormal and normal regions were recorded. The CEI from the ischemic group revealed altered myocardial texture seen as bright coarsely granular echoes in the regions normally perfused by the ligated LAD artery. Corresponding anatomic sections revealed increased redness in these regions. Microscopically these regions revealed interstitial and intercellular edema as compared to the normal regions. Acute myocardial ischemia can be visualized in CEI and these regions have significantly increased backscatter, decreased attenuation, and decreased speed of ultrasound relative to normal regions in the same hearts. Myocardial edema is probably responsible for these changes.

Original languageEnglish (US)
Pages (from-to)785-793
Number of pages9
JournalUltrasound in Medicine and Biology
Volume12
Issue number10
DOIs
StatePublished - Oct 1986

Keywords

  • 2D echo texture of ischemic myocardium
  • Myocardial ischemia
  • Ultrasound tissue characterization

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Echocardiographic visualization of acute myocardial ischemia-In vitro study'. Together they form a unique fingerprint.

  • Cite this