TY - JOUR
T1 - Echocardiographic Parameters of Mechanical Synchrony in Healthy Individuals
AU - Conca, Cristina
AU - Faletra, Francesco Fulvio
AU - Miyazaki, Chinami
AU - Oh, Jae
AU - Mantovani, Antonio
AU - Klersy, Catherine
AU - Sorgente, Antonio
AU - Pedrazzini, Giovanni Battista
AU - Pasotti, Elena
AU - Moccetti, Tiziano
AU - Auricchio, Angelo
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Definition and validation of the ranges of normal values and agreement among echocardiographic measures of mechanical synchrony in healthy subjects are mostly lacking. The aims of this study were (1) to assess the ranges of normal values for 5 tissue Doppler imaging parameters, real-time 3-dimensional echocardiographic measures, and speckle-tracking measures of mechanical synchrony; (2) to evaluate interinstitutional variability; (3) to compare the ranges of normal values with those reported in previous research; and (4) to analyze the agreement among all parameters in the same healthy subject. Time to peak systolic velocity (Ts), the delay between Ts at the basal septal and lateral segments, peak velocity difference, strain derived by tissue Doppler imaging, Ts derived by tissue synchronization imaging, systolic synchrony index (SSI) derived by real-time 3-dimensional echocardiography, and longitudinal and radial strain derived by speckle tracking were prospectively collected and analyzed at 2 different institutions in 160 consecutive healthy subjects. The ranges of normal values, expressed as means ± 2 SDs, were 30.32 ± 29.36 ms for the SD of Ts, 15.51 ± 99.88 ms for septal-lateral delay, 60.75 ± 81.62 ms for peak velocity difference, 33.07 ± 29.96 ms for tissue synchronization imaging, 34.16 ± 23.26 ms for the SD of strain, 2.74 ± 2.16% for SSI, 28.91 ± 23.02 ms for the SD of longitudinal strain, and 10.4 ± 6.31 ms for radial strain. There was large interinstitutional variability for all parameters. Three-dimensional SSI and radial strain were within the published upper range limit for healthy subjects. Ninety percent of healthy subjects were consistently classified to be synchronous by 1 parameter. With a composite index, more subjects than expected showed dyssynchrony (10% vs 2.5%). In conclusion, 3-dimensional SSI and radial strain were the most reproducible parameters and consistently discriminated normal healthy subjects from the cardiac resynchronization therapy volume responders.
AB - Definition and validation of the ranges of normal values and agreement among echocardiographic measures of mechanical synchrony in healthy subjects are mostly lacking. The aims of this study were (1) to assess the ranges of normal values for 5 tissue Doppler imaging parameters, real-time 3-dimensional echocardiographic measures, and speckle-tracking measures of mechanical synchrony; (2) to evaluate interinstitutional variability; (3) to compare the ranges of normal values with those reported in previous research; and (4) to analyze the agreement among all parameters in the same healthy subject. Time to peak systolic velocity (Ts), the delay between Ts at the basal septal and lateral segments, peak velocity difference, strain derived by tissue Doppler imaging, Ts derived by tissue synchronization imaging, systolic synchrony index (SSI) derived by real-time 3-dimensional echocardiography, and longitudinal and radial strain derived by speckle tracking were prospectively collected and analyzed at 2 different institutions in 160 consecutive healthy subjects. The ranges of normal values, expressed as means ± 2 SDs, were 30.32 ± 29.36 ms for the SD of Ts, 15.51 ± 99.88 ms for septal-lateral delay, 60.75 ± 81.62 ms for peak velocity difference, 33.07 ± 29.96 ms for tissue synchronization imaging, 34.16 ± 23.26 ms for the SD of strain, 2.74 ± 2.16% for SSI, 28.91 ± 23.02 ms for the SD of longitudinal strain, and 10.4 ± 6.31 ms for radial strain. There was large interinstitutional variability for all parameters. Three-dimensional SSI and radial strain were within the published upper range limit for healthy subjects. Ninety percent of healthy subjects were consistently classified to be synchronous by 1 parameter. With a composite index, more subjects than expected showed dyssynchrony (10% vs 2.5%). In conclusion, 3-dimensional SSI and radial strain were the most reproducible parameters and consistently discriminated normal healthy subjects from the cardiac resynchronization therapy volume responders.
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U2 - 10.1016/j.amjcard.2008.08.039
DO - 10.1016/j.amjcard.2008.08.039
M3 - Article
C2 - 19101244
AN - SCOPUS:58149460554
SN - 0002-9149
VL - 103
SP - 136
EP - 142
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 1
ER -