Echocardiographic features of idiopathic hemochromatosis

Lyle J. Olson, William P. Baldus, A. Jamil Tajik

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To characterize cardiac involvement in idiopathic hemochromatosis, clinical records and 2-dimensional (2-D) echocardiograms of 24 patients with idiopathic hemochromatosis were reviewed. The 17 men and 7 women were 24 to 80 years old (mean 48). Of 19 patients without valvular, ischemic, hypertensive or other known heart disease, 7 (37%) had structural and functional echocardiographic abnormalities attributed to idiopathic hemochromatosis (group 1) and 12 had normal echocardiographic findings (group 2). Age, gender and laboratory markers of iron overload did not differentiate patients with cardiac dysfunction (group 1) from those without cardiac dysfunction (group 2). In group 1, echocardiographic abnormalities included chamber dilatation and global systolic dysfunction. Increased wall thickness was not a feature of idiopathic hemochromatosis. All group 1 patients had abnormal electrocardiographic findings and cardiomegaly on radiography. Despite therapeutic phlebotomy, patients in this group died, between 0.5 and 30 months after echocardiography, because of congestive heart failure. In conclusion, there is a spectrum of cardiac dysfunction in idiopathic hemochromatosis. In patients with idiopathic hemochromatosis and left ventricular dysfunction, absolute wall thickness is normal. Survival is poor in patients with idiopathic hemochromatosis and severe left ventricular dysfunction.

Original languageEnglish (US)
Pages (from-to)885-889
Number of pages5
JournalThe American Journal of Cardiology
Volume60
Issue number10
DOIs
StatePublished - Oct 1 1987

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Hemochromatosis
Left Ventricular Dysfunction
Iron Overload
Phlebotomy
Cardiomegaly
Radiography
Echocardiography
Dilatation
Heart Diseases
Heart Failure
Biomarkers
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Echocardiographic features of idiopathic hemochromatosis. / Olson, Lyle J.; Baldus, William P.; Tajik, A. Jamil.

In: The American Journal of Cardiology, Vol. 60, No. 10, 01.10.1987, p. 885-889.

Research output: Contribution to journalArticle

Olson, Lyle J. ; Baldus, William P. ; Tajik, A. Jamil. / Echocardiographic features of idiopathic hemochromatosis. In: The American Journal of Cardiology. 1987 ; Vol. 60, No. 10. pp. 885-889.
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