Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle

M. De Visser, A. M. Emslie-Smith, A. G. Engel

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

In 6 adults with dermatomyositis, minimally weak or nonweak muscles that showed inconclusive light-microscopic alterations were examined by electron microscopy. In all 6 specimens, this revealed pathologic changes in endomysial capillaries. The endothelial cells harbored microtubular inclusions and microvacuoles in all cases; pale swollen endothelial cells were observed in 3 specimens. There were no significant ultrastructural changes in the muscle fibers. In all cases, a small proportion of muscle capillaries were immunoreactive for complement membrane attack complex neoantigens. The findings imply that in adult dermatomyositis capillary injury precedes muscle fiber damage and infiltration by inflammatory cells, and that the microvasculature is an early and specific target of the disease process in muscle.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalJournal of the neurological sciences
Volume94
Issue number1-3
DOIs
StatePublished - Dec 1989

Keywords

  • Capillary ultrastructure
  • Dermatomyositis
  • Human muscle
  • Membrane attack complex (MAC)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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