Early subclinical coronary artery calcification in young adults who were pediatric kidney transplant recipients

Michael B. Ishitani, Dawn S. Milliner, Dean Y. Kim, Humberto E. Bohorquez, Julie K. Heimbach, Patrick F. Sheedy, Bruce Z. Morgenstern, James M. Gloor, Joseph G. Murphy, Robert D. McBane, Lawrence F. Bielak, Patricia A. Peyser, Mark D. Stegall

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Coronary artery disease (CAD) is the leading cause of death in adults after successful kidney transplantation. Children who have undergone successful kidney transplantation are entering young adulthood; however, the prevalence and extent of CAD in this population is unknown. We conducted a pilot study in young adults with stable allograft function, who received kidney transplants as children to measure coronary artery calcification (CAC), a marker of coronary artery atherosclerosis and CAD. We evaluated 19 young adults after successful pediatric kidney transplantation for known CAD risk factors; these patients underwent noninvasive imaging with electron-beam computed tomography (EBCT) for measurement of CAC. Prevalence and quantity of CAC were then compared to asymptomatic individuals from the community. All patients had multiple risk factors for CAD. Mean age at evaluation was 32 years (range: 21-48 years). CAC is uncommon in individuals in the community in this age range; however, nearly half of our patients had CAC detected with the quantity of CAC comparable to asymptomatic individuals from the community 10-40 years older. These data suggest young adults who received pediatric kidney transplants are at increased risk for developing early CAC and need close monitoring to detect early CAD so as to prevent premature cardiac morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1689-1693
Number of pages5
JournalAmerican Journal of Transplantation
Volume5
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • Coronary artery calcification
  • Coronary heart disease
  • Electron beam computed tomography
  • Pediatric kidney transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Ishitani, M. B., Milliner, D. S., Kim, D. Y., Bohorquez, H. E., Heimbach, J. K., Sheedy, P. F., Morgenstern, B. Z., Gloor, J. M., Murphy, J. G., McBane, R. D., Bielak, L. F., Peyser, P. A., & Stegall, M. D. (2005). Early subclinical coronary artery calcification in young adults who were pediatric kidney transplant recipients. American Journal of Transplantation, 5(7), 1689-1693. https://doi.org/10.1111/j.1600-6143.2005.00914.x