Early recognition of malnutrition and cachexia in the cancer patient: A position paper of a European School of Oncology Task Force

M. Aapro, J. Arends, F. Bozzetti, Ken Fearon, S. M. Grunberg, J. Herrstedt, J. Hopkinson, N. Jacquelin-Ravel, A. Jatoi, S. Kaasa, F. Strasser

Research output: Contribution to journalReview article

136 Scopus citations

Abstract

Background: Weight loss and cachexia are common, reduce tolerance of cancer treatment and the likelihood of response, and independently predict poor outcome. Methods: A group of experts met under the auspices of the European School of Oncology to review the literature and- on the basis of the limited evidence at present-make recommendations for malnutrition and cachexia management and future research. Conclusions: Our focus should move from end-stage wasting to supporting patients' nutritional and functional state throughout the increasingly complex and prolonged course of anti-cancer treatment. When inadequate nutrient intake predominates (malnutrition), this can be managed by conventional nutritional support. In the presence of systemic inflammation/ altered metabolism (cachexia), a multi-modal approach including novel therapeutic agents is required. For all patients, oncologists should consider three supportive care issues: ensuring sufficient energy and protein intake, maintaining physical activity to maintain muscle mass and (if present) reducing systemic inflammation. The results of phase II/III trials based on novel drug targets (e.g. cytokines, ghrelin receptor, androgen receptor, myostatin) are expected in the next 2 years. If effective therapies emerge, early detection of malnutrition and cachexia will be increasingly important in the hope that timely intervention can improve both patient-centered and oncology outcomes.

Original languageEnglish (US)
Article numbermdu085
Pages (from-to)1492-1499
Number of pages8
JournalAnnals of Oncology
Volume25
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Cancer cachexia
  • Malnutrition
  • Nutritional support
  • Review
  • Systemic inflammation

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Early recognition of malnutrition and cachexia in the cancer patient: A position paper of a European School of Oncology Task Force'. Together they form a unique fingerprint.

  • Cite this

    Aapro, M., Arends, J., Bozzetti, F., Fearon, K., Grunberg, S. M., Herrstedt, J., Hopkinson, J., Jacquelin-Ravel, N., Jatoi, A., Kaasa, S., & Strasser, F. (2014). Early recognition of malnutrition and cachexia in the cancer patient: A position paper of a European School of Oncology Task Force. Annals of Oncology, 25(8), 1492-1499. [mdu085]. https://doi.org/10.1093/annonc/mdu085