TY - JOUR
T1 - Early onset epilepsy is associated with increased mortality
T2 - A population-based study
AU - Moseley, Brian D.
AU - Wirrell, Elaine C.
AU - Wong-Kisiel, Lily C.
AU - Nickels, Katherine
N1 - Funding Information:
This study was supported by a CR20 Research award from the Mayo Foundation and made possible by the Rochester Epidemiology Project (Grant No. R01-AG034676 from the National Institute on Aging). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health . The authors wish to thank Brandon Grossardt for his assistance with the statistical analysis.
PY - 2013/8
Y1 - 2013/8
N2 - We examined mortality in early onset (age < 12 months) epilepsy in a population-based group of children. Children with early onset epilepsy were significantly more likely to die (case fatality, CF 8/60 versus 8/407, p < 0.001; mortality rate, MR 14.5/1000 versus 2/1000 person years; standardized mortality ratio, SMR 22.25 versus 5.67). Mortality was greater in children with malignant neonatal (age < 1 month) epilepsy (CF 4/12 versus 12/450, p < 0.001; MR 54/1000 person years versus 2.7/1000 person year; SMR 46.55 versus 7.22). Given that only 1/8 early onset epilepsy deaths was seizure-related, mortality appears to be more affected by underlying etiology.
AB - We examined mortality in early onset (age < 12 months) epilepsy in a population-based group of children. Children with early onset epilepsy were significantly more likely to die (case fatality, CF 8/60 versus 8/407, p < 0.001; mortality rate, MR 14.5/1000 versus 2/1000 person years; standardized mortality ratio, SMR 22.25 versus 5.67). Mortality was greater in children with malignant neonatal (age < 1 month) epilepsy (CF 4/12 versus 12/450, p < 0.001; MR 54/1000 person years versus 2.7/1000 person year; SMR 46.55 versus 7.22). Given that only 1/8 early onset epilepsy deaths was seizure-related, mortality appears to be more affected by underlying etiology.
KW - Early onset epilepsy
KW - Mortality
KW - Neonatal onset epilepsy
KW - Pediatric epilepsy
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U2 - 10.1016/j.eplepsyres.2013.03.002
DO - 10.1016/j.eplepsyres.2013.03.002
M3 - Article
C2 - 23582606
AN - SCOPUS:84880036929
SN - 0920-1211
VL - 105
SP - 410
EP - 414
JO - Epilepsy Research
JF - Epilepsy Research
IS - 3
ER -