Early neuropsychological characteristics of progranulin mutation carriers

Bradley J. Hallam, Claudia Jacova, Ging Yuek R. Hsiung, Dana Wittenberg, Pheth Sengdy, Phoenix Bouchard-Kerr, Penny Slack, Rosa Rademakers, Matthew Baker, Tiffany W. Chow, Brian Levine, Howard H. Feldman, Ian R. Mackenzie

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Mutations in the progranulin gene (GRN) are a common cause of familial frontotemporal dementia. We used a comprehensive neuropsychological battery to investigate whether early cognitive changes could be detected in GRN mutation carriers before dementia onset. Twenty-four at-risk members from six families with known GRN mutations underwent detailed neuropsychological testing. Group differences were investigated by domains of attention, language, visuospatial function, verbal memory, non-verbal memory, working memory and executive function. There was a trend for mutation carriers (n=8) to perform more poorly than non-carriers (n=16) across neuropsychological domains, with significant between group differences for visuospatial function (p<.04; d=0.92) and working memory function (p<.02; d=1.10). Measurable cognitive differences exist before the development of frontotemporal dementia in subjects with GRN mutations. The neuropsychological profile of mutation carriers suggests early asymmetric, right hemisphere brain dysfunction that is consistent with recent functional imaging data from our research group and the broader literature.

Original languageEnglish (US)
Pages (from-to)694-703
Number of pages10
JournalJournal of the International Neuropsychological Society
Volume20
Issue number7
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cognitive symptom
  • FTLD with TDP-43 Pathology
  • Granulin
  • Hereditary neurodegenerative disease
  • Neuropsychology
  • Ubiquitin positive frontotemporal dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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