Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

Luis F. Porrata; David J. Inwards; Ivana N. Micallef; Stephen M. Ansell; Susan M. Geyer; Svetomir N. Markovic

doi:10.1046/j.1365-2141.2002.03478.x

Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

Luis F. Porrata, David J. Inwards, Ivana N. Micallef, Stephen M. Ansell, Susan M. Geyer, Svetomir N. Markovic

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 10⁹ cells/l compared with the 41 patients with ALC < 0.5 × 10⁹ cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.

Original language	English (US)
Pages (from-to)	629-633
Number of pages	5
Journal	British journal of haematology
Volume	117
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03478.x
State	Published - 2002

Keywords

Absolute lymphocyte count recovery
Autologous stem cell transplantation
Hodgkin's disease

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2002.03478.x

Cite this

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title = "Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease",

abstract = "A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.",

keywords = "Absolute lymphocyte count recovery, Autologous stem cell transplantation, Hodgkin's disease",

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AU - Porrata, Luis F.

AU - Inwards, David J.

AU - Micallef, Ivana N.

AU - Ansell, Stephen M.

AU - Geyer, Susan M.

AU - Markovic, Svetomir N.

PY - 2002

Y1 - 2002

N2 - A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.

AB - A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.

KW - Absolute lymphocyte count recovery

KW - Autologous stem cell transplantation

KW - Hodgkin's disease

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Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

Abstract

Keywords

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