Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

Luis F. Porrata, David J. Inwards, Ivana Micallef, Stephen Maxted Ansell, Susan M. Geyer, Svetomir Nenad Markovic

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80 Citations (Scopus)

Abstract

A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalBritish Journal of Haematology
Volume117
Issue number3
DOIs
StatePublished - 2002

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Hematopoietic Stem Cell Transplantation
Lymphocyte Count
Hodgkin Disease
Lymphocytes
Survival
Stem Cell Transplantation
Disease-Free Survival
Retrospective Studies
Transplantation

Keywords

  • Absolute lymphocyte count recovery
  • Autologous stem cell transplantation
  • Hodgkin's disease

ASJC Scopus subject areas

  • Hematology

Cite this

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abstract = "A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.",
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T1 - Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

AU - Porrata, Luis F.

AU - Inwards, David J.

AU - Micallef, Ivana

AU - Ansell, Stephen Maxted

AU - Geyer, Susan M.

AU - Markovic, Svetomir Nenad

PY - 2002

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AB - A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC ≥ 0.5 × 109 cells/l compared with the 41 patients with ALC < 0.5 × 109 cells/l ('not yet reached' versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.

KW - Absolute lymphocyte count recovery

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