Early heparinization decreases the incidence of left atrial thrombi detected by intracardiac echocardiography during radiofrequency ablation for atrial fibrillation

Charles J Bruce, Paul Andrew Friedman, Om Narayan, Thomas M. Munger, Stephen C. Hammill, Douglas L Packer, Samuel J Asirvatham

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Introduction: We reviewed our experience in managing intracardiac ultrasound-detected left atrial thrombus and analyzed the impact of the timing of heparin therapy on thrombus incidence. Methods and Results: We identified 508 patients undergoing ablation procedures for atrial fibrillation in which intracardiac ultrasound was used. All patients received unfractionated heparin during the procedure: 31 patients before the first transseptal puncture (preTS1), 257 between the first and second transseptal punctures (TS1-TS2), and 220 following both punctures (postTS2). By using intracardiac echocardiography (ICE), thrombus was detected in 30 of these 508 patients (5.9%). Of these, 29 were in the left atrium and constituted our study group. In 21 patients, the thrombi were successfully aspirated from the left atrium using strong suction through the transseptal sheath. All patients in whom thrombi were aspirated did well without neurological event or death. When patients received heparin therapy either preTS1 or TS1-TS2, there was a significant decrease in the occurrence of ICE-detected left atrial thrombus compared with those who received heparin postTS2 (0 of 31 patients (0%) preTS, 9 of 257 (3.5%) TS1-TS2, and 20 of 220 (9.1%) postTS2; (preTS1 vs postTS2, p=0.01; preTS2 [preTS1 and TS1-TS2] vs postTS2, p<0.001). Conclusion: Early administration of intravenous heparin, specifically before transseptal puncture, decreases the incidence of left atrial thrombi.

Original languageEnglish (US)
Pages (from-to)211-219
Number of pages9
JournalJournal of Interventional Cardiac Electrophysiology
Volume22
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Atrial Fibrillation
Echocardiography
Thrombosis
Incidence
Heparin
Punctures
Heart Atria
Suction
Intravenous Administration
Therapeutics

Keywords

  • Anticoagulation
  • Atrial fibrillation
  • Intracardiac echocardiography
  • Radiofrequency ablation
  • Thrombus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{e460981a6e884ae9a11d8498aa73d920,
title = "Early heparinization decreases the incidence of left atrial thrombi detected by intracardiac echocardiography during radiofrequency ablation for atrial fibrillation",
abstract = "Introduction: We reviewed our experience in managing intracardiac ultrasound-detected left atrial thrombus and analyzed the impact of the timing of heparin therapy on thrombus incidence. Methods and Results: We identified 508 patients undergoing ablation procedures for atrial fibrillation in which intracardiac ultrasound was used. All patients received unfractionated heparin during the procedure: 31 patients before the first transseptal puncture (preTS1), 257 between the first and second transseptal punctures (TS1-TS2), and 220 following both punctures (postTS2). By using intracardiac echocardiography (ICE), thrombus was detected in 30 of these 508 patients (5.9{\%}). Of these, 29 were in the left atrium and constituted our study group. In 21 patients, the thrombi were successfully aspirated from the left atrium using strong suction through the transseptal sheath. All patients in whom thrombi were aspirated did well without neurological event or death. When patients received heparin therapy either preTS1 or TS1-TS2, there was a significant decrease in the occurrence of ICE-detected left atrial thrombus compared with those who received heparin postTS2 (0 of 31 patients (0{\%}) preTS, 9 of 257 (3.5{\%}) TS1-TS2, and 20 of 220 (9.1{\%}) postTS2; (preTS1 vs postTS2, p=0.01; preTS2 [preTS1 and TS1-TS2] vs postTS2, p<0.001). Conclusion: Early administration of intravenous heparin, specifically before transseptal puncture, decreases the incidence of left atrial thrombi.",
keywords = "Anticoagulation, Atrial fibrillation, Intracardiac echocardiography, Radiofrequency ablation, Thrombus",
author = "Bruce, {Charles J} and Friedman, {Paul Andrew} and Om Narayan and Munger, {Thomas M.} and Hammill, {Stephen C.} and Packer, {Douglas L} and Asirvatham, {Samuel J}",
year = "2008",
month = "9",
doi = "10.1007/s10840-008-9270-x",
language = "English (US)",
volume = "22",
pages = "211--219",
journal = "Journal of Interventional Cardiac Electrophysiology",
issn = "1383-875X",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Early heparinization decreases the incidence of left atrial thrombi detected by intracardiac echocardiography during radiofrequency ablation for atrial fibrillation

AU - Bruce, Charles J

AU - Friedman, Paul Andrew

AU - Narayan, Om

AU - Munger, Thomas M.

AU - Hammill, Stephen C.

AU - Packer, Douglas L

AU - Asirvatham, Samuel J

PY - 2008/9

Y1 - 2008/9

N2 - Introduction: We reviewed our experience in managing intracardiac ultrasound-detected left atrial thrombus and analyzed the impact of the timing of heparin therapy on thrombus incidence. Methods and Results: We identified 508 patients undergoing ablation procedures for atrial fibrillation in which intracardiac ultrasound was used. All patients received unfractionated heparin during the procedure: 31 patients before the first transseptal puncture (preTS1), 257 between the first and second transseptal punctures (TS1-TS2), and 220 following both punctures (postTS2). By using intracardiac echocardiography (ICE), thrombus was detected in 30 of these 508 patients (5.9%). Of these, 29 were in the left atrium and constituted our study group. In 21 patients, the thrombi were successfully aspirated from the left atrium using strong suction through the transseptal sheath. All patients in whom thrombi were aspirated did well without neurological event or death. When patients received heparin therapy either preTS1 or TS1-TS2, there was a significant decrease in the occurrence of ICE-detected left atrial thrombus compared with those who received heparin postTS2 (0 of 31 patients (0%) preTS, 9 of 257 (3.5%) TS1-TS2, and 20 of 220 (9.1%) postTS2; (preTS1 vs postTS2, p=0.01; preTS2 [preTS1 and TS1-TS2] vs postTS2, p<0.001). Conclusion: Early administration of intravenous heparin, specifically before transseptal puncture, decreases the incidence of left atrial thrombi.

AB - Introduction: We reviewed our experience in managing intracardiac ultrasound-detected left atrial thrombus and analyzed the impact of the timing of heparin therapy on thrombus incidence. Methods and Results: We identified 508 patients undergoing ablation procedures for atrial fibrillation in which intracardiac ultrasound was used. All patients received unfractionated heparin during the procedure: 31 patients before the first transseptal puncture (preTS1), 257 between the first and second transseptal punctures (TS1-TS2), and 220 following both punctures (postTS2). By using intracardiac echocardiography (ICE), thrombus was detected in 30 of these 508 patients (5.9%). Of these, 29 were in the left atrium and constituted our study group. In 21 patients, the thrombi were successfully aspirated from the left atrium using strong suction through the transseptal sheath. All patients in whom thrombi were aspirated did well without neurological event or death. When patients received heparin therapy either preTS1 or TS1-TS2, there was a significant decrease in the occurrence of ICE-detected left atrial thrombus compared with those who received heparin postTS2 (0 of 31 patients (0%) preTS, 9 of 257 (3.5%) TS1-TS2, and 20 of 220 (9.1%) postTS2; (preTS1 vs postTS2, p=0.01; preTS2 [preTS1 and TS1-TS2] vs postTS2, p<0.001). Conclusion: Early administration of intravenous heparin, specifically before transseptal puncture, decreases the incidence of left atrial thrombi.

KW - Anticoagulation

KW - Atrial fibrillation

KW - Intracardiac echocardiography

KW - Radiofrequency ablation

KW - Thrombus

UR - http://www.scopus.com/inward/record.url?scp=48349130322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48349130322&partnerID=8YFLogxK

U2 - 10.1007/s10840-008-9270-x

DO - 10.1007/s10840-008-9270-x

M3 - Article

C2 - 18568395

AN - SCOPUS:48349130322

VL - 22

SP - 211

EP - 219

JO - Journal of Interventional Cardiac Electrophysiology

JF - Journal of Interventional Cardiac Electrophysiology

SN - 1383-875X

IS - 3

ER -