Early hemorrhage growth in patients with intracerebral hemorrhage

Thomas Brott, Joseph Broderick, Rashmi Kothari, William Barsan, Thomas Tomsick, Laura Sauerbeck, Judith Spilker, John Duldner, Jane Khoury

Research output: Contribution to journalArticle

1044 Scopus citations

Abstract

Background and Purpose: The goal of the present study was to prospectively determine how frequently early growth of intracerebral hemorrhage occurs and whether this early growth is related to early neurological deterioration. Methods: We performed a prospective observational study of patients with intracerebral hemorrhage within 3 hours of onset. Patients had a neurological evaluation and CT scan performed at baseline, 1 hour after baseline, and 20 hours after baseline. Results: Substantial growth in the volume of parenchymal hemorrhage occurred in 26% of the 103 study patients between the baseline and 1-hour CT scans. An additional 12% of patients had substantial growth between the 1- and 20- hour CT scans. Hemorrhage growth between the baseline and 1-hour CT scans was significantly associated with clinical deterioration, as measured by the change between the baseline and 1-hour Glasgow Coma Scale and National Institutes of Health Stroke Scale scores. No baseline clinical or CT prediction of hemorrhage growth was identified. Conclusions: Substantial early hemorrhage growth in patients with intracerebral hemorrhage is common and is associated with neurological deterioration. Randomized treatment trials are needed to determine whether this early natural history of ongoing bleeding and frequent neurological deterioration can be improved.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalStroke
Volume28
Issue number1
DOIs
StatePublished - Jan 1997

Keywords

  • computed tomography
  • intracerebral hemorrhage
  • prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Brott, T., Broderick, J., Kothari, R., Barsan, W., Tomsick, T., Sauerbeck, L., Spilker, J., Duldner, J., & Khoury, J. (1997). Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke, 28(1), 1-5. https://doi.org/10.1161/01.STR.28.1.1