Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice

Jia Min Zhuo, Sonya L. Prescott, Melissa E. Murray, Hai Yan Zhang, Mark G. Baxter, Michelle M. Nicolle

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

To understand the relationship between amyloid-β and cognitive decline in Alzheimer's disease, we evaluated cortical and hippocampal function in a transgenic mouse model of amyloid over-expression in Alzheimer's disease, the Tg2576 mouse. Tg2576 mice and their non-transgenic littermates were assessed at both 6 and 14 months of age in a battery of cognitive tests: attentional set-shifting, water maze spatial reference memory and T-maze working memory. Spatial reference memory was not affected by Tg status at either age. Working memory was only affected by age, with 6-month-old mice performing better than 14-month-old ones. Older mice were also significantly impaired on reversal learning and on the intra- and extra-dimensional shift in attentional set-shifting. A significant transgene effect was apparent in reversal learning, with Tg2576 mice requiring more trials to reach criterion at 6 months old. These data indicate that the effects of normal aging in C57B6 × SJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Aβ load only affects discrimination reversal learning in our study.

Original languageEnglish (US)
Pages (from-to)1248-1257
Number of pages10
JournalNeurobiology of aging
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2007

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Frontal cortex
  • Hippocampus
  • Set-shifting
  • T-maze
  • Water maze
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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