Early Detection of Sporadic Pancreatic Cancer

Summative Review

Suresh T Chari, Kimberly Kelly, Michael A. Hollingsworth, Sarah P. Thayer, David A. Ahlquist, Dana K. Andersen, Surinder K. Batra, Teresa A. Brentnall, Marcia Canto, Deborah F. Cleeter, Matthew A. Firpo, Sanjiv Sam Gambhir, Vay Liang W Go, O. Joe Hines, Barbara J. Kenner, David S. Klimstra, Markus M. Lerch, Michael J. Levy, Anirban Maitra, Sean J. Mulvihill & 7 others Gloria M Petersen, Andrew D. Rhim, Diane M. Simeone, Sudhir Srivastava, Masao Tanaka, Aaron I. Vinik, David Wong

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.

Original languageEnglish (US)
Pages (from-to)693-712
Number of pages20
JournalPancreas
Volume44
Issue number5
DOIs
StatePublished - Jul 25 2015

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Pancreatic Neoplasms
Anniversaries and Special Events
Pancreas
Cause of Death
Japan
Biomarkers
Research Personnel
Research
Neoplasms

Keywords

  • biomarker
  • diabetes
  • familial
  • imaging
  • pancreatic ductal adenocarcinoma
  • screening

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., ... Wong, D. (2015). Early Detection of Sporadic Pancreatic Cancer: Summative Review. Pancreas, 44(5), 693-712. https://doi.org/10.1097/MPA.0000000000000368

Early Detection of Sporadic Pancreatic Cancer : Summative Review. / Chari, Suresh T; Kelly, Kimberly; Hollingsworth, Michael A.; Thayer, Sarah P.; Ahlquist, David A.; Andersen, Dana K.; Batra, Surinder K.; Brentnall, Teresa A.; Canto, Marcia; Cleeter, Deborah F.; Firpo, Matthew A.; Gambhir, Sanjiv Sam; Go, Vay Liang W; Hines, O. Joe; Kenner, Barbara J.; Klimstra, David S.; Lerch, Markus M.; Levy, Michael J.; Maitra, Anirban; Mulvihill, Sean J.; Petersen, Gloria M; Rhim, Andrew D.; Simeone, Diane M.; Srivastava, Sudhir; Tanaka, Masao; Vinik, Aaron I.; Wong, David.

In: Pancreas, Vol. 44, No. 5, 25.07.2015, p. 693-712.

Research output: Contribution to journalArticle

Chari, ST, Kelly, K, Hollingsworth, MA, Thayer, SP, Ahlquist, DA, Andersen, DK, Batra, SK, Brentnall, TA, Canto, M, Cleeter, DF, Firpo, MA, Gambhir, SS, Go, VLW, Hines, OJ, Kenner, BJ, Klimstra, DS, Lerch, MM, Levy, MJ, Maitra, A, Mulvihill, SJ, Petersen, GM, Rhim, AD, Simeone, DM, Srivastava, S, Tanaka, M, Vinik, AI & Wong, D 2015, 'Early Detection of Sporadic Pancreatic Cancer: Summative Review', Pancreas, vol. 44, no. 5, pp. 693-712. https://doi.org/10.1097/MPA.0000000000000368
Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK et al. Early Detection of Sporadic Pancreatic Cancer: Summative Review. Pancreas. 2015 Jul 25;44(5):693-712. https://doi.org/10.1097/MPA.0000000000000368
Chari, Suresh T ; Kelly, Kimberly ; Hollingsworth, Michael A. ; Thayer, Sarah P. ; Ahlquist, David A. ; Andersen, Dana K. ; Batra, Surinder K. ; Brentnall, Teresa A. ; Canto, Marcia ; Cleeter, Deborah F. ; Firpo, Matthew A. ; Gambhir, Sanjiv Sam ; Go, Vay Liang W ; Hines, O. Joe ; Kenner, Barbara J. ; Klimstra, David S. ; Lerch, Markus M. ; Levy, Michael J. ; Maitra, Anirban ; Mulvihill, Sean J. ; Petersen, Gloria M ; Rhim, Andrew D. ; Simeone, Diane M. ; Srivastava, Sudhir ; Tanaka, Masao ; Vinik, Aaron I. ; Wong, David. / Early Detection of Sporadic Pancreatic Cancer : Summative Review. In: Pancreas. 2015 ; Vol. 44, No. 5. pp. 693-712.
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