Early detection and treatment of cholangiocarcinoma

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Key Points. 1. The major identified risk factor for the development of cholangiocarcinoma in Western countries is primary sclerosing cholangitis (PSC). 2. The diagnosis of cholangiocarcinoma in PSC requires a high index of suspicion because endoscopic brush cytology and/or biopsies and imaging studies are often negative for malignancy. Positron emission tomography is a promising imaging modality for the diagnosis of cholangiocarcinoma, even in patients with PSC. 3. A serum carbohydrate antigen 19-9 value greater than 100 U/mL has a sensitivity and specificity for cholangiocarcinoma of approximately 75% and 80%, respectively. 4. Liver transplantation is a viable therapeutic option for selected patients with early-stage cholangiocarcinoma. Outcomes are optimized by using preoperative radiation and chemotherapy and ensuring the absence of metastases by an exploratory laparotomy.

Original languageEnglish (US)
JournalLiver Transplantation
Volume6
Issue number6 SUPPL. 2
StatePublished - 2000

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Cholangiocarcinoma
Sclerosing Cholangitis
Therapeutics
Positron-Emission Tomography
Liver Transplantation
Laparotomy
Cell Biology
Carbohydrates
Radiation
Neoplasm Metastasis
Biopsy
Antigens
Drug Therapy
Sensitivity and Specificity
Serum
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Early detection and treatment of cholangiocarcinoma. / Gores, Gregory James.

In: Liver Transplantation, Vol. 6, No. 6 SUPPL. 2, 2000.

Research output: Contribution to journalArticle

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