Abstract
We report on a family in which individuals at risk for NF 2 were investigated with the use of gadolinium-enhanced MRI. This technique has allowed the diagnosis of small (< 8 mm) acoustic neuromas in two asymptomatic children (age 7 and 11), one of whom had normal audiometric and brainstem- evoked response testing. To our knowledge these are the youngest asymptomatic patients in whom the diagnosis of NF 2 has been demonstrated. It is possible that acoustic neuromas develop at an early age more commonly than recognized previously. The early diagnosis of acoustic neuromas with the use of gadolinium-enhanced MRI may lead to better outcome following surgery. This technique will provide the opportunity to better determine the natural course of this disease.
Original language | English (US) |
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Pages (from-to) | 325-329 |
Number of pages | 5 |
Journal | American journal of medical genetics |
Volume | 41 |
Issue number | 3 |
DOIs | |
State | Published - 1991 |
Keywords
- acoustic neuromas
- cerebellopontine angle
- gadolinium
- magnetic resonance imaging
- neurofibromatosis 2
ASJC Scopus subject areas
- Genetics(clinical)