Early childhood diagnosis of acoustic neuromas in presymptomatic individuals at risk for neurofibromatosis 2

G. M. Pastores, V. V. Michels, C. R. Jack

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report on a family in which individuals at risk for NF 2 were investigated with the use of gadolinium-enhanced MRI. This technique has allowed the diagnosis of small (< 8 mm) acoustic neuromas in two asymptomatic children (age 7 and 11), one of whom had normal audiometric and brainstem- evoked response testing. To our knowledge these are the youngest asymptomatic patients in whom the diagnosis of NF 2 has been demonstrated. It is possible that acoustic neuromas develop at an early age more commonly than recognized previously. The early diagnosis of acoustic neuromas with the use of gadolinium-enhanced MRI may lead to better outcome following surgery. This technique will provide the opportunity to better determine the natural course of this disease.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalAmerican journal of medical genetics
Volume41
Issue number3
DOIs
StatePublished - Jan 1 1991

Keywords

  • acoustic neuromas
  • cerebellopontine angle
  • gadolinium
  • magnetic resonance imaging
  • neurofibromatosis 2

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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