Early changes in myocardial microcirculation in asymptomatic hypercholesterolemic subjects: As detected by perfusion CT

Thomas R. Behrenbeck, Cynthia H. McCollough, Wayne L. Miller, Eric E. Williamson, Shuai Leng, Timothy L. Kline, Erik L. Ritman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Intramyocardial microvessels show functional changes in early stages of atherosclerosis prior to epicardial coronary artery stenosis. However, clinical CT does not have adequate spatial resolution to resolve the microvessels. To clinically detect changes in the function of the intramyocardial microcirculation, the spatial heterogeneity of the distribution of myocardial perfusion (F) and intramyocardial microcirculatory blood volume (Bv) was determined by perfusion CT. Two human subject groups were studied: (i) a "Control" group (24) with no risk factors nor evidence of coronary artery disease (CAD), and (ii) an "At-Risk" group (24) with hypercholester-olemia, but no evidence of CAD. In the perfusion CT image, a region of interest (ROI) covering the left ventricular myocardium was subdivided into multiple nested ROI (nROI) of equal size and used to compute F and Bv for each nROI. No significant differences between the groups were demonstrable in overall myocardial F, or Bv. The nROI data showed significantly increased spatial heterogeneity in the "At Risk" group when comparedto "Control" subjects. Thisstudy demonstrates that subresolution distribution at the microcirculatory level can be quantified with myocardial perfusion CT and significant changes in these parameters occur in hypercholesterolemic subjects before they have developed significant changes in conventional perfusion parameters.

Original languageEnglish (US)
Pages (from-to)515-525
Number of pages11
JournalAnnals of Biomedical Engineering
Volume42
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Atherosclerosis
  • Capillaries
  • Coronary artery disease
  • Microcirculation
  • Regional blood flow

ASJC Scopus subject areas

  • Biomedical Engineering

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