Early blood pressure response to isometric exercise is attenuated in obese individuals who have undergone bariatric surgery

Jacqueline K. Limberg, Winston Guo, Michael J. Joyner, Nisha Charkoudian, Timothy B. Curry

Research output: Contribution to journalArticle

Abstract

Blood pressure (BP) reactivity is predictive of the development of cardiovascular disease. We hypothesized that the BP response at the onset of isometric handgrip exercise would occur earlier and to a lesser degree in individuals who underwent bariatric surgery compared with obese adults and that the reliance on total peripheral resistance (TPR) would be attenuated. Twenty-six individuals (7 nonobese, 11 obese, 8 postbariatric surgery) completed isometric handgrip exercise (40% maximum voluntary contraction) to exhaustion. Heart rate (HR, ECG) and arterial BP (brachial catheter) were measured continuously. Stroke volume was estimated from the pressure waveform, and cardiac output (CO) and TPR were calculated. Peak change, time to peak, and rate of rise in BP were assessed during the first 30 s of exercise. Obese adults exhibited a slower rise in BP and higher peak BP at exercise onset compared with nonobese controls (P < 0.05). Peak BP and the rate of rise were not different between individuals who underwent bariatric surgery and nonobese controls (P < 0.05). Nonobese controls exhibited an exercise- mediated increase in CO, whereas obese adults increased TPR (P < 0.05). The increases in CO and TPR were less apparent in individuals who underwent bariatric surgery (P < 0.05). In contrast to obese adults, individuals who underwent bariatric surgery exhibit a rapid rise in BP at exercise onset. This rapid increase in BP is associated with a fall in TPR and results in lower peak BP at the onset of isometric exercise. These data suggest that bariatric surgery improves BP reactivity via changes in the time course of hemodynamic responses. NEW & NOTEWORTHY Bariatric surgery has been shown to reduce the blood pressure (BP) response to isometric handgrip exercise. By examining the time course of the BP response to exercise, we found, in contrast to obese adults, individuals who underwent bariatric surgery exhibit a rapid rise in BP at exercise onset, which is associated with a fall in total peripheral resistance and results in lower peak BP at the onset of isometric exercise. These data suggest that bariatric surgery improves BP reactivity via reflex autonomic adjustments.

Original languageEnglish (US)
Pages (from-to)960-969
Number of pages10
JournalJournal of applied physiology
Volume124
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Autonomic
  • Baroreflex sensitivity
  • Gastric bypass
  • Heart rate variability

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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