Early atherosclerosis aggravates the effect of renal artery stenosis on the swine kidney

Victor H. Urbieta-Caceres, Ronit Lavi, Xiang Yang Zhu, John A. Crane, Stephen C Textor, Amir Lerman, Lilach O Lerman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Atherosclerotic renal artery stenosis (ARAS) is increasingly identified in patients with end-stage renal disease. Renal function in ARAS patients deteriorates more frequently than in nonatherosclerotic renal artery stenosis (RAS). This study was designed to test the hypothesis that atherosclerosis modifies the relationship between single-kidney hemodynamics and function and the severity of stenosis. The degree of unilateral RAS in domestic pigs (4 normal, 26 RAS, and 22 ARAS) was correlated with renal function and hemodynamics evaluated by 64-slice multidetector computerized tomography before and after endothelium-dependent challenge with ACh. The degree of stenosis and increase in mean arterial pressure were similar in RAS and ARAS. Stenotic single-kidney volume, blood flow, glomerular filtration rate, and cortical perfusion were lower than normal in both RAS and ARAS, but only in RAS correlated inversely with increasing degree of stenosis (r = -0.62, r = -0.49, r = -0.51, and r = -0.46, respectively, P < 0.05 for all). Basal tubular fluid concentration capacity and stenotic cortical perfusion response to ACh were both blunted only in ARAS. This study shows that atherosclerosis modulates the impact of a stenosis in the renal artery on stenotic kidney hemodynamics, function, and tubular dynamics. These observations underscore the direct intrarenal effect of atherogenic factors on the kidneys.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume299
Issue number1
DOIs
StatePublished - Jul 2010

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Renal Artery Obstruction
Atherosclerosis
Swine
Kidney
Pathologic Constriction
Hemodynamics
Perfusion
Sus scrofa
Blood Volume
Glomerular Filtration Rate
Chronic Kidney Failure
Endothelium
Arterial Pressure

Keywords

  • Multidetector CT
  • Renovascular hypertension

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Early atherosclerosis aggravates the effect of renal artery stenosis on the swine kidney. / Urbieta-Caceres, Victor H.; Lavi, Ronit; Zhu, Xiang Yang; Crane, John A.; Textor, Stephen C; Lerman, Amir; Lerman, Lilach O.

In: American Journal of Physiology - Renal Physiology, Vol. 299, No. 1, 07.2010.

Research output: Contribution to journalArticle

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