Early atherosclerosis aggravates renal micro vascular loss and fibrosis inswine renal artery stenosis

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Renal function in patients with atherosclerosis and renal artery stenosis (ARAS) deteriorates more frequently than in nonatherosclerotic RAS. We hypothesized that ARAS aggravates stenotic-kidney micro vascular loss compared to RAS. Domestic pigs were randomized to normal, RAS, and ARAS (RAS fed a high-cholesterol diet) groups (n=7 each). Ten weeks later stenotic-kidney oxygenation, renal blood flow, and glomerular filtration rate (GFR) were evaluated invivo, and micro vascular density by micro-computed tomography. Blood pressure in both RAS and ARAS was elevated; and stenotic-kidney renal blood flow and GFR similarly decreased. RAS decreased the density of small-size cortical microvessels (

Original languageEnglish (US)
JournalJournal of the American Society of Hypertension
DOIs
StateAccepted/In press - Nov 25 2015

Keywords

  • Atherosclerosis
  • Fibrosis
  • Micro vascular injury
  • Renal artery stenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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