Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older

C. J. Mullany, G. E. Darling, J. R. Pluth, T. A. Orszulak, Hartzell V Schaff, D. M. Ilstrup, B. J. Gersh

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Abstract

We have studied 159 patients 80 years of age or older who have had isolated coronary artery bypass grafting (CABG) since 1977. Eighty-seven percent have had surgery since 1984. Two thirds of the patients were male, and the mean age was 82 years. Most patients (97%) were in New York Heart Association (NYHA) functional class III or IV, 89% had unstable/postinfarction angina pectoris, and 67% had rest pain. Almost half (47%) required preoperative admission to the coronary care unit, 6% required preoperative use of an intra-aortic balloon pump, and 20% were operated on emergently. Significant left main coronary artery disease (≥ 50% stenosis) was present in 41%. Ten patients (6.3%) died within 30 days of surgery, with seven more patients dying during the same hospital admission or soon after transfer to another institution. This resulted in an overall hospital mortality of 10.7%. The median hospital stay was 10 days. On univariate analysis, the significant predictors of hospital mortality were NYHA IV, angina at rest, preoperative admission to the coronary care unit, emergency operation, ejection fraction less than 0.50, and the presence of mitral regurgitation. On multivariate analysis, ejection fraction less than 0.50 was the only significant risk factor (p < 0.01). Of hospital survivors, 98% have been followed for a mean of 29 months. The estimated 5-year survival (± SEM) of all patients was 71 ± 4.5%, and for hospital survivors, 80 ± 4.5%. The most important predictor of adverse survival was an ejection fraction less than 0.50. Seventy-nine percent are angina-free, and 89% are in NYHA classes I and II. The majority of patients felt that they were improved by surgery. We conclude that CABG in patients 80 years or older, although associated with increased operative risk, gives excellent relief of symptoms and good 5-year survival. Patients should not be denied CABG because of age alone.

Original languageEnglish (US)
JournalCirculation
Volume82
Issue number5 SUPPL.
StatePublished - 1990

Fingerprint

Coronary Artery Bypass
Coronary Care Units
Unstable Angina
Hospital Mortality
Survival
Survivors
Mitral Valve Insufficiency
Ambulatory Surgical Procedures
Coronary Artery Disease
Length of Stay
Pathologic Constriction
Emergencies
Multivariate Analysis
Pain

Keywords

  • Coronary artery bypass graft
  • Elderly
  • Long-term outcome

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mullany, C. J., Darling, G. E., Pluth, J. R., Orszulak, T. A., Schaff, H. V., Ilstrup, D. M., & Gersh, B. J. (1990). Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older. Circulation, 82(5 SUPPL.).

Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older. / Mullany, C. J.; Darling, G. E.; Pluth, J. R.; Orszulak, T. A.; Schaff, Hartzell V; Ilstrup, D. M.; Gersh, B. J.

In: Circulation, Vol. 82, No. 5 SUPPL., 1990.

Research output: Contribution to journalArticle

Mullany, CJ, Darling, GE, Pluth, JR, Orszulak, TA, Schaff, HV, Ilstrup, DM & Gersh, BJ 1990, 'Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older', Circulation, vol. 82, no. 5 SUPPL..
Mullany CJ, Darling GE, Pluth JR, Orszulak TA, Schaff HV, Ilstrup DM et al. Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older. Circulation. 1990;82(5 SUPPL.).
Mullany, C. J. ; Darling, G. E. ; Pluth, J. R. ; Orszulak, T. A. ; Schaff, Hartzell V ; Ilstrup, D. M. ; Gersh, B. J. / Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older. In: Circulation. 1990 ; Vol. 82, No. 5 SUPPL.
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abstract = "We have studied 159 patients 80 years of age or older who have had isolated coronary artery bypass grafting (CABG) since 1977. Eighty-seven percent have had surgery since 1984. Two thirds of the patients were male, and the mean age was 82 years. Most patients (97{\%}) were in New York Heart Association (NYHA) functional class III or IV, 89{\%} had unstable/postinfarction angina pectoris, and 67{\%} had rest pain. Almost half (47{\%}) required preoperative admission to the coronary care unit, 6{\%} required preoperative use of an intra-aortic balloon pump, and 20{\%} were operated on emergently. Significant left main coronary artery disease (≥ 50{\%} stenosis) was present in 41{\%}. Ten patients (6.3{\%}) died within 30 days of surgery, with seven more patients dying during the same hospital admission or soon after transfer to another institution. This resulted in an overall hospital mortality of 10.7{\%}. The median hospital stay was 10 days. On univariate analysis, the significant predictors of hospital mortality were NYHA IV, angina at rest, preoperative admission to the coronary care unit, emergency operation, ejection fraction less than 0.50, and the presence of mitral regurgitation. On multivariate analysis, ejection fraction less than 0.50 was the only significant risk factor (p < 0.01). Of hospital survivors, 98{\%} have been followed for a mean of 29 months. The estimated 5-year survival (± SEM) of all patients was 71 ± 4.5{\%}, and for hospital survivors, 80 ± 4.5{\%}. The most important predictor of adverse survival was an ejection fraction less than 0.50. Seventy-nine percent are angina-free, and 89{\%} are in NYHA classes I and II. The majority of patients felt that they were improved by surgery. We conclude that CABG in patients 80 years or older, although associated with increased operative risk, gives excellent relief of symptoms and good 5-year survival. Patients should not be denied CABG because of age alone.",
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AB - We have studied 159 patients 80 years of age or older who have had isolated coronary artery bypass grafting (CABG) since 1977. Eighty-seven percent have had surgery since 1984. Two thirds of the patients were male, and the mean age was 82 years. Most patients (97%) were in New York Heart Association (NYHA) functional class III or IV, 89% had unstable/postinfarction angina pectoris, and 67% had rest pain. Almost half (47%) required preoperative admission to the coronary care unit, 6% required preoperative use of an intra-aortic balloon pump, and 20% were operated on emergently. Significant left main coronary artery disease (≥ 50% stenosis) was present in 41%. Ten patients (6.3%) died within 30 days of surgery, with seven more patients dying during the same hospital admission or soon after transfer to another institution. This resulted in an overall hospital mortality of 10.7%. The median hospital stay was 10 days. On univariate analysis, the significant predictors of hospital mortality were NYHA IV, angina at rest, preoperative admission to the coronary care unit, emergency operation, ejection fraction less than 0.50, and the presence of mitral regurgitation. On multivariate analysis, ejection fraction less than 0.50 was the only significant risk factor (p < 0.01). Of hospital survivors, 98% have been followed for a mean of 29 months. The estimated 5-year survival (± SEM) of all patients was 71 ± 4.5%, and for hospital survivors, 80 ± 4.5%. The most important predictor of adverse survival was an ejection fraction less than 0.50. Seventy-nine percent are angina-free, and 89% are in NYHA classes I and II. The majority of patients felt that they were improved by surgery. We conclude that CABG in patients 80 years or older, although associated with increased operative risk, gives excellent relief of symptoms and good 5-year survival. Patients should not be denied CABG because of age alone.

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