Abstract
Translocations involving the IgH locus at chromosomal locus 14q32.3 are a common event in many B-cell malignancies. The translocations, which generally occur into JH and switch regions, are mediated by errors in the two developmentally regulated, lymphocyte-specific pathways: VDJ- and switch- mediated recombination. Dysregulation of cyclin D1 by a t(11; 14)(q13;q32) translocation occurs in most cases of mantle-cell lymphoma and in approximately 30% of multiple myeloma (MM) tumors in which a 14q32 translocation can be detected. We show here that in two of three myeloma lines that overexpress cyclin D1, there is an 11;14 translocation into a gamma switch region, suggesting an error in switch recombination. By contrast, 11;14 translocations in mantle-cell lymphoma are invariably into or near a JH segment, suggesting an error in VDJ recombination. This is consistent with the fact that myeloma cells have undergone IgH switch recombination, whereas mantle-cell lymphoma cells generally have not.
Original language | English (US) |
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Pages (from-to) | 674-681 |
Number of pages | 8 |
Journal | Blood |
Volume | 88 |
Issue number | 2 |
DOIs | |
State | Published - Jul 15 1996 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology