Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines

Marta Chesi, P. Leif Bergsagel, Leslie A. Brents, Carissa M. Smith, Daniela S. Gerhard, W. Michael Kuehl

Research output: Contribution to journalArticle

219 Scopus citations

Abstract

Translocations involving the IgH locus at chromosomal locus 14q32.3 are a common event in many B-cell malignancies. The translocations, which generally occur into JH and switch regions, are mediated by errors in the two developmentally regulated, lymphocyte-specific pathways: VDJ- and switch- mediated recombination. Dysregulation of cyclin D1 by a t(11; 14)(q13;q32) translocation occurs in most cases of mantle-cell lymphoma and in approximately 30% of multiple myeloma (MM) tumors in which a 14q32 translocation can be detected. We show here that in two of three myeloma lines that overexpress cyclin D1, there is an 11;14 translocation into a gamma switch region, suggesting an error in switch recombination. By contrast, 11;14 translocations in mantle-cell lymphoma are invariably into or near a JH segment, suggesting an error in VDJ recombination. This is consistent with the fact that myeloma cells have undergone IgH switch recombination, whereas mantle-cell lymphoma cells generally have not.

Original languageEnglish (US)
Pages (from-to)674-681
Number of pages8
JournalBlood
Volume88
Issue number2
StatePublished - Jul 15 1996

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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